Raboz 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.00 (50's pack: ৳ 250.00)

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Leon pharmaceuticals ltd

Indications

  • Treatment of active duodenal ulcer
  • Treatment of active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Long-term management of gastro-esophageal reflux disease (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Treatment of Zollinger-Ellison Syndrome
  • Eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

  • Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase
  • Characterized as a gastric proton-pump inhibitor

Dosage

  • Recommended oral dose for active duodenal ulcer and active benign gastric ulcer is 20 mg once daily
  • Recommended oral dose for erosive or ulcerative gastro-esophageal reflux disease (GERD) is 20 mg once daily for four to eight weeks
  • Maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily can be used depending upon patient response for long-term management of GERD

Administration

  • Rabeprazole tablets should be taken in the morning, before eating
  • Tablets should not be chewed or crushed, but should be swallowed whole

Interaction

  • Potential interaction with compounds whose absorption is pH dependent
  • Co-administration with ketoconazole or itraconazole may result in a significant decrease in antifungal plasma levels
  • No interaction with liquid antacids was observed
  • Avoid co-administration with atazanavir

Contraindications

  • Hypersensitivity to the active substance or to any of the excipients
  • Contra-indicated in pregnancy and during breastfeeding

Side Effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy & Lactation

  • US FDA pregnancy category 'C'
  • No adequate and well-controlled studies in pregnant women
  • Likely to be excreted in human milk

Precautions & Warnings

  • Symptomatic response to therapy does not preclude the presence of gastric or oesophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • May increase the risk of hip, wrist, and spine fracture, predominantly in the elderly or in presence of other recognised risk factors
  • Patients at risk of osteoporosis should have an adequate intake of vitamin D and calcium
  • A risk of cross-hypersensitivity reactions with other proton pump inhibitor or substituted benzimidazoles cannot be excluded
  • May increase the risk of gastrointestinal infections such as Salmonella, Campylobacter, and Clostridium difficile

Use in Special Populations

  • No dosage adjustment is necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to a lack of data on safety and efficacy

Overdose Effects

  • Effects are generally minimal, representative of the known adverse event profile and reversible without further medical intervention
  • No specific antidote is known

Therapeutic Class

  • Proton Pump Inhibitor

Storage Conditions

  • Keep below 30°C temperature, away from light & moisture

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions about Raboz 20 mg Tablet

  • Proton pump inhibitor (PPI) that suppresses gastric acid secretion
  • Used to treat duodenal ulcer, gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
  • Common side effects include diarrhea, constipation, nausea, and vomiting
  • Should be taken with food and not more than the prescribed dose
  • Not recommended for use during pregnancy or breastfeeding
  • Can cause dry mouth and constipation
  • Long-term use can cause thinning of bones (osteoporosis)

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