Rapo 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.25 (6 x 10: ৳ 315.00)

Strip Price: ৳ 52.50

Medicine Details

Category	Details
Generic	Rabeprazole sodium
Company	Medicon pharmaceuticals ltd

Title

Rapo Gastro-resistant Tablets 20mg

Description

Rapo Gastro-resistant tablets provide relief for conditions such as active duodenal ulcer, active benign gastric ulcer, GERD, Zollinger-Ellison Syndrome, and H. pylori eradication. The tablets contain rabeprazole, which suppresses gastric acid secretion by inhibiting the H+/K+-ATPase in the gastric parietal cell.

Indication

Active duodenal ulcer
Active benign gastric ulcer
Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
Zollinger-Ellison Syndrome
Eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

Suppresses gastric acid secretion by inhibiting the gastric H+/K+-ATPase at the secretory surface of the gastric parietal cell.

Dosage

20 mg once daily in the morning for active duodenal ulcer and active benign gastric ulcer
20 mg once daily for four to eight weeks for Erosive or Ulcerative Gastro-Esophageal Reflux Disease (GERD)
Maintenance dose of 20 mg or 10 mg once daily for long-term management of GERD
10 mg once daily for symptomatic treatment of moderate to very severe Gastro-Esophageal Reflux Disease (symptomatic GERD)
60-120 mg once daily for Zollinger-Ellison Syndrome
Combination therapy with clarithromycin and amoxicillin for H. pylori eradication

Administration

Take in the morning before eating, swallow whole without chewing or crushing.

Interaction

Potential interaction with pH-dependent compounds
May decrease plasma levels of ketoconazole or itraconazole
No interaction with liquid antacids

Contraindications

Hypersensitivity to the active substance or excipients
Contra-indicated in pregnancy and during breastfeeding

Side effects

Headache
Diarrhea
Abdominal pain
Vomiting
Constipation
Dry mouth
Muscle pain
Drowsiness
Dizziness

Pregnancy and lactation

US FDA pregnancy category 'C'. Likely excreted in human milk; decision should be made whether to discontinue nursing or the drug, considering importance to the mother.

Precautions and warnings

Symptomatic response does not preclude the presence of malignancy
Regular surveillance for long-term treatment
Increased risk of hip, wrist, and spine fracture in high doses and over long durations
Risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles
Hypomagnesaemia reported in long-term use
May reduce the absorption of vitamin B12
Potential association with subacute cutaneous lupus erythematosus (SCLE)
May interfere with investigations for neuroendocrine tumors

Special populations

No dosage adjustment for renal or hepatic impairment
Not recommended for use in children due to lack of data on safety and efficacy

Overdose effects

Maximum exposure not exceeded 160 mg once daily; effects typically reversible without specific antidote, treatment should be symptomatic and general supportive measures.

Therapeutic class

Proton Pump Inhibitor

Storage conditions

Keep below 30°C temperature, away from light & moisture, and out of the reach of children.

Chemical structure

Molecular formula: C18H21N3O3S
Chemical structure image: https://medex.com.bd/storage/res/g-res-942-rabeprazole-sodium-chemical-structure-atwg0Q4PlndQZhOY9GHX.svg

Common questions

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