Rabecare 20 mg (Tablet (Enteric Coated))

Unit Price: ৳ 5.02

Medicine Details

Category Details
Generic Rabeprazole sodium
Company Novelta bestway pharma ltd

Indications

  • Active duodenal ulcer
  • Active benign gastric ulcer
  • Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
  • Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • Zollinger-Ellison Syndrome
  • In combination with appropriate antibacterial therapeutic regimens for the eradication of Helicobacter pylori in patients with peptic ulcer disease

Pharmacology

Rabeprazole suppresses gastric acid secretion by inhibiting the gastric H⁺/K⁺-ATPase at the secretory surface of the gastric parietal cell.

Dosage

  • 20 mg once daily in the morning for active duodenal ulcer and active benign gastric ulcer
  • 20 mg once daily for four to eight weeks for erosive or ulcerative gastro-esophageal reflux disease (GERD)
  • 20 mg or 10 mg once daily for long-term management of GERD
  • 10 mg once daily for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
  • 5 mg once daily for pediatric patients 1 to 11 years of age (Less than 15 kg) for 12 weeks with the option to increase to 10 mg if inadequate response
  • 10 mg once daily for pediatric patients 1 to 11 years of age (15 kg or more) for 12 weeks
  • 60 mg once a day for Zollinger-Ellison Syndrome with possibility of titrating upwards to 120 mg/day based on individual patient needs
  • Combination therapy for H. pylori eradication: rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily, and amoxicillin 1g twice daily for 7 days

Administration

Rabeprazole tablets should be taken in the morning, before eating, and should be swallowed whole without chewing or crushing.

Interaction

May interact with compounds whose absorption is pH dependent. Co-administration with ketoconazole or itraconazole may result in a significant decrease in antifungal plasma levels. No interaction with liquid antacids was observed. The absorption of atazanavir is pH-dependent, therefore should not be co-administered with rabeprazole.

Contraindications

Hypersensitivity to the active substance or excipients. Contraindicated in pregnancy and during breastfeeding.

Side Effects

  • Headache
  • Diarrhoea
  • Abdominal pain
  • Vomiting
  • Constipation
  • Dry mouth
  • Increased or decreased appetite
  • Muscle pain
  • Drowsiness
  • Dizziness

Pregnancy & Lactation

US FDA pregnancy category 'C'. No adequate and well-controlled studies in pregnant women. Likely to be excreted in human milk.

Precautions & Warnings

  • Symptomatic response does not preclude the presence of gastric or oesophageal malignancy
  • Patients on long-term treatment should be kept under regular surveillance
  • May modestly increase the risk of hip, wrist, and spine fracture
  • A risk of cross-hypersensitivity reactions with other proton pump inhibitors or substituted benzimidazoles cannot be excluded
  • Hepatic enzyme abnormalities observed and should be monitored
  • Severe hypomagnesaemia has been reported in patients treated with PPIs
  • May reduce the absorption of vitamin B12
  • Associated with very infrequent cases of subacute cutaneous lupus erythematosus
  • Increased Chromogranin A (CgA) level may interfere with investigations for neuroendocrine tumours

Use in Special Populations

  • No dosage adjustment is necessary for patients with renal or hepatic impairment
  • Not recommended for use in children due to lack of data on safety and efficacy

Overdose Effects

Effects are generally minimal, representative of the known adverse event profile, reversible without further medical intervention. No specific antidote is known.

Therapeutic Class

Proton Pump Inhibitor

Storage Conditions

Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.

Chemical Structure

  • Molecular Formula: C18H21N3O3S

Common Questions about Rabecare 20 mg Tablet

  • Rabeprazole 20 mg Tablet is a proton pump inhibitor (PPI) that suppresses gastric acid secretion.
  • Used to treat duodenal ulcer, gastric ulcer, GERD, Zollinger-Ellison Syndrome, and Helicobacter pylori eradication.
  • Common side effects include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, dry mouth, and rare serious side effects such as kidney problems, liver damage, and bone fractures.
  • Should be taken with food and not recommended for use during pregnancy or breastfeeding. Overdose can cause symptoms such as drowsiness, confusion, and seizures.

Related Brands