Rabprazo 20 mg (Tablet (Enteric Coated))
Unit Price: ৳ 6.50 (5 x 10: ৳ 325.00)
Strip Price: ৳ 65.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rabeprazole sodium |
| Company | Pacific pharmaceuticals ltd |
Therapeutic Category
- Proton Pump Inhibitor
Dosage
- 20 mg once daily in the morning for active duodenal ulcer and active benign gastric ulcer
- 20 mg once daily for four to eight weeks for erosive or ulcerative gastro-esophageal reflux disease (GERD)
- 20 mg or 10 mg once daily for long-term management of GERD
- 10 mg once daily for symptomatic treatment of moderate to very severe gastro-esophageal reflux disease
- 5 mg once daily for pediatric patients 1 to 11 years of age (Less than 15 kg)
- 10 mg once daily for pediatric patients 1 to 11 years of age (15 kg or more)
- 60 mg once daily for Zollinger-Ellison Syndrome, may be titrated upwards to 120 mg/day based on patient needs
- 20 mg twice daily in combination with antibiotics for Helicobacter pylori eradication
Indications
- Active duodenal ulcer
- Active benign gastric ulcer
- Symptomatic erosive or ulcerative gastro-esophageal reflux disease (GERD)
- Gastro-esophageal Reflux Disease Long-term Management (GERD Maintenance)
- Symptomatic treatment of moderate to very severe gastro-esophageal reflux disease (symptomatic GERD)
- Zollinger-Ellison Syndrome
- Helicobacter pylori eradication in patients with peptic ulcer disease
Administration
- To be taken in the morning, before eating
- Tablets should not be chewed or crushed, but swallowed whole
Interaction
- Potential interaction with pH-dependent compounds
- Co-administration with ketoconazole or itraconazole may decrease antifungal plasma levels
- No interaction with liquid antacids observed
- Co-administration with atazanavir not recommended
Contraindications
- Hypersensitivity to the active substance or excipients
- Contra-indicated in pregnancy and during breastfeeding
Side Effects
- Well-tolerated
- Common: headache, diarrhea, abdominal pain, vomiting, constipation, dry mouth, changes in appetite, muscle pain, drowsiness, dizziness
Pregnancy & Lactation
- FDA pregnancy category 'C'
- No adequate and well-controlled studies in pregnant women
- Drug likely to be excreted in human milk
- Risk and benefit analysis advised for breastfeeding mothers
Precautions & Warnings
- Symptomatic response to therapy does not exclude the presence of gastric or esophageal malignancy
- Regular surveillance for patients on long-term treatment
- Possible increase in risk of hip, wrist, and spine fracture with long-term use
- Risk of cross-hypersensitivity reactions
- Caution in patients at risk of osteoporosis
- Reports of blood dyscrasias and hepatic enzyme abnormalities
- No clinical data on use in patients with severe hepatic dysfunction
- Possible increase in risk of gastrointestinal infections
- Hypomagnesaemia may occur after prolonged use
- Reduction in vitamin B12 absorption due to hypo- or a-chlorhydria
- Rare association with subacute cutaneous lupus erythematosus (SCLE)
- Interference with investigations for neuroendocrine tumors
- Caution in patients with reduced body stores of vitamin B12 or risk factors for reduced absorption
- Avoid long-term use in children
Use in Special Populations
- No dosage adjustment necessary for patients with renal or hepatic impairment
- Not recommended for use in children
Overdose Effects
- Maximum established exposure has not exceeded specified doses
- Effects generally minimal and reversible
- No specific antidote known
Storage Conditions
- Keep below 30°C temperature, away from light and moisture
- Keep out of the reach of children
Chemical Structure
- Molecular Formula: C18H21N3O3S
- Chemical Structure available
Common Questions
- Purpose of Rabprazo 20 mg Tablet
- Common uses include treatment of Duodenal ulcer, Gastric ulcer, GERD, Zollinger-Ellison Syndrome, Helicobacter pylori eradication
- Side effects may include diarrhea, constipation, nausea, vomiting, headache, dizziness, rash, dry mouth, kidney problems, liver damage, bone fractures
- Tablets should be taken with food, and overdose can cause symptoms such as drowsiness, confusion, seizures
- Treatment duration determined by the condition being treated
- Caution advised for pregnant or breastfeeding individuals
- Potential effects on bone health, recommendations for vitamin D supplementation, and quick tips for managing side effects