Unipril 1.25 mg (Tablet)
Unit Price: ৳ 2.51 (3 x 10: ৳ 75.30)
Strip Price: ৳ 25.10
Medicine Details
| Category | Details |
|---|---|
| Generic | Ramipril |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Lowering blood pressure
- Treating hypertension
- Managing congestive heart failure
- Post-myocardial infarction treatment
- Treating glomerular or incipient nephropathy
- Reducing cardiovascular risk
- Hypertension as single-drug therapy
- Hypertension in combination therapy
- Congestive heart failure in combination with diuretics
- Renal impairment treatment
Pharmacology
- ACE inhibitor
- Blocks angiotensin-converting enzyme
- Decreases plasma angiotensin II
- Decreases vasopressor activity
- Reduces aldosterone secretion
- Long-acting
Dosage
- Initial dose adjustment
- Titration based on patient tolerance and response
- Hypertension dosage
- Congestive heart failure post-myocardial infarction dosage
- Prevention of major cardiovascular events dosage
- Dosage adjustment in renal impairment
Administration
- Oral administration
- Administration with liquid
- Non-interference with food intake
Interaction
- Concomitant administration with diuretics
- Potential for hypotension
- Interaction with potassium-sparing diuretics
- Concomitant therapy with lithium
- Effect on serum lithium concentration
- Alcohol interaction
- Interaction with NSAIDs
- Impact on antihypertensive effect
- Effect on renal function
Contraindications
- Hypersensitivity to ramipril
- History of angioedema
- Concomitant use with sacubitril/valsartan therapy
- Haemodynamically relevant renal artery stenosis
- Hypotensive or haemodynamically unstable states
- Concomitant use with aliskiren-containing medicines
- Concomitant use with angiotensin II receptor antagonists (AIIRAs)
- Pregnancy
- Concomitant use with extracorporeal treatments
Side Effects
- Dizziness
- Headache
- Fatigue
- Asthenia
- Symptomatic hypotension
- Cough
- Nausea
- Vomiting
- Diarrhoea
- Rash
- Urticaria
- Oliguria
- Anxiety
- Amnesia
- Angioneurotic oedema
- Anaphylactic reactions
- Hyperkalaemia
Pregnancy & Lactation
- Not to be taken during pregnancy
- Exclusion of pregnancy before treatment
- Avoidance of pregnancy during treatment
- Discontinuation of treatment if pregnancy occurs
- Risk of harm to the fetus
- Not recommended during breastfeeding
Precautions & Warnings
- Caution in impaired renal function
- Caution in hyperkalaemia
- Caution in hypotension
- Caution in impaired hepatic function
Use in Special Populations
- Reduced initial dose in elderly
- Initiation under close medical supervision in hepatic impairment
- Dosage adjustment in renal impairment
- Consideration for patients pretreated with a diuretic
Overdose Effects
- Excessive peripheral vasodilatation
- Hypotension and shock
- Bradycardia
- Electrolyte disturbances
- Renal failure
- Management strategies
Therapeutic Class
- ACE inhibitors
Storage Conditions
- Temperature storage at or below 30°C
- Protection from light
- Keep out of the reach of children
- Expiration date adherence
- Dispensing only on prescription