Ranitec 150 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Apc pharma ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal hemorrhage from stress ulcer in seriously ill patient
- Recurrent hemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
Competitively blocks histamine at H2-receptors of the gastric parietal cells which inhibits gastric acid secretion. Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin.
Dosage & Administration
- Usual dosage of 150 mg twice daily for 4 to 8 weeks for duodenal and gastric ulcer
- Dosage of 150 mg twice daily for up to 8 weeks for reflux esophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- 150 mg at night for preventing recurrences
- Dosage for children (peptic ulcer) of 2-4 mg/kg twice daily, maximum 300 mg daily
- Dosage for IV injection & IV Infusion based on specific conditions and patient type
Interaction
Delayed absorption and increased peak serum concentration with propantheline bromide. Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam, and propranolol. May alter absorption of pH-dependent drugs and reduce bioavailability with antacids.
Contraindications
Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- Excreted in human breast milk. Caution should be exercised when administered to a nursing mother.
Precautions & Warnings
Should be given in reduced dosage to patients with impaired renal and hepatic function.
Use in Special Populations
Ulcer healing rates found similar in elderly patients as in younger patients, with no difference in the incidence of adverse effects.
Overdose Effects
Ranitidine is very specific in action and accordingly no particular problems are expected following overdosage with the drug. Symptomatic and supportive therapy should be given as appropriate. If required, the drug may be removed from the plasma by hemodialysis.
Therapeutic Class
H2 receptor antagonist
Reconstitution
- Ranitidine 50 mg diluted to specific concentrations for slow IV inj, intermittent slow IV infusion, and continuous IV infusion. Different dilution recommendations for specific conditions.
Storage Conditions
Store in a cool and dry place. Protect from light.