Jovran 150 mg (Tablet)
Unit Price: ৳ 2.00 (10 x 10: ৳ 200.00)
Strip Price: ৳ 20.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Belsen pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion
- Does not affect serum gastrin
Dosage & Administration
- Usual dosage is 150 mg twice daily for duodenal and gastric ulcer
- 300 mg as a single daily dose at night for duodenal and gastric ulcer
- 150 mg twice daily for reflux esophagitis
- 300 mg at bedtime for reflux esophagitis
- 150 mg 3 times daily for Zollinger Ellison syndrome
- Maintenance dosage of 150 mg at night
- Dosage for children with peptic ulcer: 2-4 mg/kg twice daily
- Oral dosage for children with peptic ulcer: 2 mg/kg to 4 mg/kg twice daily
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of certain drugs
- May alter absorption of pH-dependent drugs
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- Caution advised during pregnancy
- Excreted in human breast milk
- Caution advised during lactation
Precautions & Warnings
- Reduced dosage for patients with impaired renal function
- Reduced dosage for patients with impaired hepatic function
Use in Special Populations
- Use in elderly patients: ulcer healing rates similar in patients age 65 and over
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy suggested
- Hemodialysis may be used if required
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Various reconstitution methods for different situations e.g. slow IV injection, intermittent slow IV infusion, continuous IV infusion
- Specific dilution recommendations for Zollinger-Ellison syndrome
- Use of different solvents for dilution
Storage Conditions
- Store in a cool and dry place
- Protect from light