Protec R 150 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Globex pharmaceuticals ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particularly obstetric patients
Pharmacology
- Blocks histamine at H2-receptors of the gastric parietal cells
- Inhibits gastric acid secretion
- Does not affect pepsin secretion, pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage & Administration
- Dosage for duodenal and gastric ulcer: 150 mg twice daily taken in the morning and evening or 300 mg as a single daily dose at night for 4 to 8 weeks
- Reflux oesophagitis dosage: 150 mg twice daily or 300 mg at bedtime for up to 8 weeks
- Zollinger Ellison syndrome dosage: 150 mg 3 times daily and increased if necessary up to 6 g daily in divided doses
- Episodic dyspepsia dosage: 150 mg twice daily or 300 mg at bedtime for up to 6 weeks
- Maintenance dosage: 150 mg at night for preventing recurrences
- Ranitidine IV injection & IV Infusion details
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Pregnancy: Ranitidine crosses the placenta
- Lactation: Ranitidine is excreted in human breast milk
Precautions & Warnings
- Protec R should be given in reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Use in elderly patients
Overdose Effects
- Protec R is very specific in action and accordingly no particular problems are expected following overdosage with the drug
- Symptomatic and supportive therapy should be given as appropriate
- If required, the drug may be removed from the plasma by haemodialysis
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Reconstitution details for slow IV inj, intermittent slow IV infusion, and continuous IV infusion
- Dilution instructions for patients with Zollinger-Ellison syndrome or other hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light