Ranifast 150 mg (Tablet)
Unit Price: ৳ 2.00 (100's pack: ৳ 200.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Ranitidine hydrochloride |
| Company | Sn pharmaceutical ltd |
Indications
- Treatment of active duodenal ulcer
- Benign gastric ulcer
- Treatment & prevention of ulcer associated with non-steroidal anti-inflammatory agent
- Post operative stress ulcer
- Zollinger-Ellison Syndrome
- Gastroesophageal reflux disease (GERD)
- Gastro-intestinal haemorrhage from stress ulcer in seriously ill patient
- Recurrent haemorrhage in patients with bleeding peptic ulcer
- Before general anesthesia in patient considered to be at risk of acid aspiration particulary obstetric patients
Pharmacology
- Competitively blocks histamine at H2-receptors
- Inhibits gastric acid secretion
- Does not affect pepsin secretion
- Does not affect pentagastrin-stimulated intrinsic factor secretion or serum gastrin
Dosage & Administration
- Usual dosage of 150 mg twice daily for active duodenal ulcer
- Usual dosage of 150 mg twice daily for benign gastric ulcer
- Usual dosage of 150 mg 3 times daily for Zollinger Ellison syndrome
- Usual dosage of 150 mg twice daily for episodic dyspepsia
- Maintenance dosage of 150 mg at night for preventing recurrences
- Oral dose for children (peptic ulcer) is 2-4 mg/kg twice daily, maximum 300 mg daily
- Intravenous injection given over a period of at least two minutes
- Intermittent intravenous infusion at a rate of 25 mg per hour for two hours
- Intramuscular injection of 50 mg every six to eight hours
- Oral dose for the treatment of peptic ulcer in children is 2 mg/kg to 4 mg/kg twice daily to a maximum of 300 mg ranitidine per day
Interaction
- Delayed absorption and increased peak serum concentration with propantheline bromide
- Minimally inhibits hepatic metabolism of coumarin anticoagulants, theophylline, diazepam and propanolol
- May alter absorption of pH-dependent drugs (e.g. ketoconazole, midazolam, glipizide)
- May reduce bioavailability with antacids
Contraindications
- Patients hypersensitive to Ranitidine
Side Effects
- Altered bowel habit
- Dizziness
- Rash
- Tiredness
- Reversible confusional states
- Headache
- Decreased blood counts
- Muscle or joint pain
Pregnancy & Lactation
- Ranitidine crosses the placenta
- No evidence of impaired fertility or harm to the foetus due to Ranitidine
- Ranitidine excreted in human breast milk
- Caution should be exercised when the drug is administered to a nursing mother
Precautions & Warnings
- Reduced dosage to patients with impaired renal and hepatic function
Use in Special Populations
- Ulcer healing rates similar in elderly patients
Overdose Effects
- No particular problems expected following overdosage
- Symptomatic and supportive therapy should be given as appropriate
- Drug may be removed from the plasma by haemodialysis
Therapeutic Class
- H2 receptor antagonist
Reconstitution
- Ranitidine 50 mg should be diluted to specific concentrations for slow IV inj, intermittent slow IV infusion, continuous IV infusion
- Specific dilution instructions for patients with Zollinger-Ellison syndrome or other hypersecretory conditions
Storage Conditions
- Store in a cool and dry place
- Protect from light