Efaxim 200 mg (Tablet)
Unit Price: ৳ 20.00 (1 x 10: ৳ 200.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rifaximin |
| Company | Square pharmaceuticals plc |
| Also available as |
Indications
- Treatment of traveler's diarrhea by noninvasive strains of E. coli
- Reduction in risk of overt hepatic encephalopathy
- Bacterial overgrowth of irritable bowel syndrome
Pharmacology
- Semisynthetic rifamycin-based non-systemic antibiotic
- Inhibits bacterial RNA synthesis by action on the beta-subunit of the DNA-dependent RNA polymerase
- Broad spectrum activity against Gram-positive and Gram-negative, aerobic and anaerobic bacteria
Dosage & Administration
- Traveler's Diarrhea: 200mg 3 times daily for 3 days (patients ≥12 years)
- Hepatic Encephalopathy: 550mg 2 times daily (patients ≥18 years)
- Bacterial overgrowth of irritable bowel syndrome: 400mg 3 times daily for 10 days or 550mg 3 times daily for 14 days
Interaction
- In vitro study suggests Efaxim induces CYP3A4
- Efaxim at recommended dosing regimen not expected to induce CYP3A4 in patients with normal liver function
Contraindications
- Hypersensitivity to Rifaximin or to any rifamycin antimicrobial agents or any components of this product
Side Effects
- Flatulence
- Headache
- Abdominal pain
- Rectal tenesmus
- Defecation urgency
- Nausea
- Constipation
- Pyrexia
- Vomiting
- Other reported reactions: anaphylaxis, angioneurotic edema, exfoliative dermatitis
Pregnancy & Lactation
- Pregnancy category C
- Unknown excretion in human milk
Precautions & Warnings
- Not effective in patients with diarrhea complicated by fever and/or blood in the stools
- Discontinue therapy if diarrhea symptoms worsen or persist for more than 24-48 hours
- Consider alternative antibiotic therapy if needed
- Pseudomembranous colitis reported with antibacterial agents
Use in Special Populations
- Renal Impairment: Pharmacokinetics in patients with impaired renal function not studied
- Hepatic Impairment: Markedly elevated systemic exposure in patients with hepatic impairment
Overdose Effects
- No specific information available on treatment of overdose with Efaxim
- Discontinue, treat symptomatically, and institute supportive measures as required in case of overdose
Therapeutic Class
4-Quinolone preparations
Storage Conditions
Below 30°C, away from light & moisture, keep out of reach of children