Rofumil 500 mcg (Tablet)
Unit Price: ৳ 10.05 (2 x 10: ৳ 201.00)
Strip Price: ৳ 100.50
Medicine Details
| Category | Details |
|---|---|
| Generic | Roflumilast tablet |
| Company | Drug international ltd |
Indications
- Maintenance treatment of severe COPD
- Associated with chronic bronchitis
- Add on to bronchodilator treatment
- Adult patients with frequent exacerbations
Pharmacology
- Phosphodiesterase-4 (PDE-4) inhibitor
- Selective inhibition of PDE4 isoenzyme
- Potential antiinflammatory effects
- Antimodulatory effects
- Increased levels of intracellular cyclic AMP
Dosage & Administration
- Recommended dose 500 micrograms once daily
- May take several weeks to achieve effect
- Studied in clinical trials for up to one year
- Swallow with water
- Take at the same time every day
Interaction
- No proven hazardous interactions
- Case report of interaction with ethanol
- Case report of potentiation with betahistine and salbutamol
- Concurrent administration of H1 antagonists may cause mutual attenuation of effects
Contraindications
- Hypersensitivity to Roflumilast or excipients
- Moderate or severe hepatic impairment
Side Effects
- Adverse reactions in approximately 16% of patients
- Commonly reported: diarrhea, weight decreased, nausea, abdominal pain, headache
- Majority of reactions were mild or moderate
- Occur mainly within the first weeks of therapy
Pregnancy & Lactation
- Not recommended during pregnancy
- Has shown reproductive toxicity in animal studies
- Crosses the placenta in pregnant rats
- Not recommended during breastfeeding
Precautions & Warnings
- Inform patients about risks and precautions
- Not indicated as rescue medicinal product for acute bronchospasms
- Weight decrease observed in patients
- Special clinical conditions for use
- Increased risk of psychiatric disorders and suicidal ideation
- Reassessment in case of persistent intolerability
- Concomitant treatment precautions
Overdose Effects
- Observed symptoms at increased rate after overdose
- Appropriate supportive medical care recommended
- Haemodialysis not likely to be effective method of removal
Therapeutic Class
- Antihistamines anti-allergies & hypo-sensitisation
Storage Conditions
- Store below 30°C
- Keep away from light and moisture
- Keep out of the reach of children