Onamis 8 mg (Tablet)
Unit Price: ৳ 3.67 (3 x 30: ৳ 330.00)
Strip Price: ৳ 110.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ondansetron |
| Company | Apex pharmaceuticals ltd |
Indications
- Prevention of nausea and vomiting associated with initial and repeat courses of emetogenic cancer chemotherapy
- Prevention and treatment of post-operative nausea and vomiting
- Prevention of radiotherapy-induced nausea and vomiting
Description
- Oral soluble film designed to be applied on top of the tongue
- Dissolves within 20 seconds
- Active ingredient: Ondansetron base
- Formula: C18H19N3O
- Molecular weight: 293.3
Pharmacology
- Potent, highly selective 5HT3 receptor-antagonist
- Precise mode of action not fully known
- Blocks initiation of vomiting reflex
- Blocks 5HT3 receptors in peripheral and central nervous system
Dosage
- Doses for adults, pediatric patients, and pediatric patients (6 months to 18 years)
- Different doses for Chemotherapy-Induced Nausea and Vomiting, Radiotherapy-Induced Nausea and Vomiting, and Postoperative Nausea and Vomiting
Administration
- Instructions for administration of Oral Soluble Film
- Steps for application and swallowing
Interaction
- Metabolized by hepatic cytochrome P-450 drug-metabolizing enzymes
- Inducers or inhibitors may change clearance and half-life of Ondansetron
Contraindications
- Contraindicated in patients with hypersensitivity to the drug or its components
- Concomitant use of apomorphine
Side Effects
- Frequently reported adverse events: headache, constipation, diarrhea
- Occasional occurrences of rash, sensation of flushing or warmth, hiccups, and liver enzyme abnormalities
- Rare cases of anaphylaxis, bronchospasm, tachycardia, chest pain, hypokalemia, shortness of breath
Pregnancy & Lactation
- Carcinogenic effects not seen in animal studies
- No evidence of impaired fertility or harm to the fetus in animal studies
- Caution advised when administered to nursing women
Precautions & Warnings
- Hypersensitivity reactions reported in some patients
- Not a drug that stimulates gastric or intestinal peristalsis
- Should not be used instead of nasogastric suction in certain conditions
Use in Special Populations
- Dosage recommendations for patients with impaired renal or hepatic function
- Limited information available for pediatric patients 4 years of age or younger
Therapeutic Class
- Anti-emetic drugs
Storage Conditions
- Store at temperature not exceeding 30°C
- Protect from light and moisture