Liconor 150 mg (Tablet)
Unit Price: ৳ 11.04 (3 x 10: ৳ 331.20)
Strip Price: ৳ 110.40
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Opsonin pharma ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
Reduces cholesterol saturation of bile and promotes dissolution of gallstones. Reduces cholesterol secretion into bile and increases bile acid secretion rate.
Pharmacology
- Decreases secretion of cholesterol in bile
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Promotes formation of liquid cholesterol crystal complexes
Mode of Action
- Protects cholangiocytes against cytotoxicity of hydrophobic bile acids
- Stimulates hepatobilliary secretion
- Protects hepatocytes against bile acid-induced apoptosis
- Completely absorbed in the upper intestine
- Time to peak serum concentration varies from 30 to 150 minutes
- Rate of absorption ranges from 60-80%
Dosage & Administration
- Dissolution of Gall stones: 8-12 mg/kg/day
- Primary Billiary Cirrhosis: 10-15 mg/kg/day
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
Interaction
Should not be used with drugs that increase bile cholesterol. Concomitant administration with bile-acid binding drugs should be avoided.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm reported. Effectively used for treatment of cholestasis of pregnancy. Problems not documented in humans regarding breastfeeding.
Precautions & Warnings
Should be used cautiously in those with liver disease.
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C. Protected from light and moisture. Keep out of reach of children.