Largix 10 mg (Tablet)
Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Rupatadine fumarate |
| Company | Aci limited |
| Also available as |
Indications
- Symptomatic treatment of Seasonal & Perennial Allergic Rhinitis
- Symptomatic treatment of Urticaria
Pharmacology
- Rupatadine is a long-acting, non-sedative antagonist of histamine H1-receptors
- Antagonizes platelet activating factor (PAF)
- Inhibition of degranulation of mast cells
- Inhibition of release of cytokines
Dosage & Administration
- Adults and Adolescents (over 12 years): 10 mg once a day
- Children aged 2 to 11 years:
- Children weighing 25 kg or more: 1 teaspoonful (5 ml) of oral solution once daily
- Children weighing equal or more than 10 kg to less than 25 kg: 1/2 teaspoonful (2.5 ml) oral solution once daily
Interaction
- Concomitant administration with ketoconazole or erythromycin increases systemic exposure
- Caution with statins, CNS depressants, or alcohol
- Avoid simultaneous intake with grapefruit and grapefruit juice
Contraindications
- Hypersensitivity to Rupatadine or any excipients
Side Effects
- Common: Asthenia, dizziness, drowsiness
- Uncommon: Appetite increased, arthralgia, back pain, concentration impaired, constipation, cough, diarrhea, dry throat, epistaxis, fever, gastrointestinal discomfort, increased risk of infection, irritability, malaise, myalgia, nasal dryness, nausea, oropharyngeal pain, rash, thirst, vomiting, weight increased
- Rare: Palpitations, tachycardia
Pregnancy & Lactation
- No clinical data available on exposure during pregnancy
- Not recommended during lactation unless benefits justify risks
Precautions & Warnings
- Use with caution in patients with known prolongation of the QT interval, hypokalemia, proarrhythmic conditions, or in elderly patients
Use in Special Populations
- Elderly: Use with caution, no requirement of dose adjustment known
- Children: Safety and efficacy not established in patients less than 12 years of age
- Patients with renal or hepatic insufficiency: Not recommended, as no relevant clinical data available
Overdose Effects
- Most common adverse reaction is somnolence
- Accidental ingestion of very high doses may necessitate symptomatic treatment
Therapeutic Class
Non-sedating antihistamines
Storage Conditions
Store in cool & dry place below 30°C, protect from light & moisture, keep out of reach of children
Chemical Structure
- Molecular Formula: C26H26ClN3
Common Questions about Largix 10 mg Tablet
- Largix 10 mg Tablet is H1-receptors antagonist and antagonizes platelet activating factor (PAF)
- Commonly used to treat seasonal & perennial allergic rhinitis and urticaria
- Unsafe to use during pregnancy, uncertain impact on breastfeeding
- No data available on impact on driving, advice for caution in renal impairment, unknown impact on liver function
- Onset of action within 75 minutes, duration of action between 8 to 10 hours
- Quick Tips from doctor's prescription