Oxycol 300 mg (Tablet)
Unit Price: ৳ 36.00 (2 x 10: ৳ 720.00)
Strip Price: ৳ 360.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Unimed unihealth pharmaceuticals ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
Used to reduce cholesterol saturation of bile and promote dissolution of gallstones. Reduces cholesterol secretion into bile and increases bile acid secretion rate without reduction in phospholipids.
Pharmacology
- Decreases secretion of cholesterol in bile
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Promotes formation of liquid cholesterol crystal complexes
- Improves cholestatic liver diseases by protecting cholangiocytes, stimulating hepatobilliary secretion, protecting hepatocytes against bile acid-induced apoptosis
- Completely absorbed in the upper intestine with a variable time to peak serum concentration and absorption rate
- Undergoes extraction from portal blood by liver, conjugated with amino acid, secreted into hepatic bile ducts, with small quantities appearing in circulation and very small amounts excreted into urine
- Biologic half-life ranges from 3.5-5.8 days
Dosage & Administration
- Dissolution of Gallstones: 8-12 mg/kg/day
- Primary Billiary Cirrhosis: 10-15 mg/kg/day
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
- Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day
Interaction
Should not be used with oestrogenic hormones or bile-acid binding drugs including antacids, charcoal, and cholestyramine.
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B. No evidence of harm reported in pregnancy. Effectively used for cholestasis treatment during the last trimester. No documented problems regarding breastfeeding.
Precautions & Warnings
Should be used cautiously in those with liver disease.
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C. Protected from light and moisture. Keep out of reach of children.