Uliv 300 mg (Tablet)
Unit Price: ৳ 25.00 (1 x 10: ৳ 250.00)
Strip Price: ৳ 250.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Ursodeoxycholic acid |
| Company | Acme laboratories ltd |
| Also available as |
Indications
- Cholestasis (Jaundice)
- Viral Hepatitis
- Alcoholic Fatty Liver
- Primary Billiary Cirrhosis (PBC)
- Primary Sclerosing Cholangitis (PSC)
- Dissolution of Gallstones
- Non-Alcoholic Steato Hepatitis (NASH)
Description
Reduces cholesterol saturation of bile, promotes dissolution of gallstones, reduces cholesterol secretion into bile, increases bile acid secretion rate.
Pharmacology
- Decrease in secretion of cholesterol in bile
- Reduces cholesterol absorption
- Suppresses liver cholesterol synthesis
- Alters bile composition from supersaturated to unsaturated
- Promotes formation of liquid cholesterol crystal complexes
- Improves cholestatic liver diseases by protecting cholangiocytes, stimulating hepatobilliary secretion, protecting hepatocytes against bile acid-induced apoptosis
- Completely absorbed in the upper intestine, varies from 30 to 150 minutes for time to peak serum concentration, ranges from 60-80% for absorption rate, biologic half life ranges from 3.5-5.8 days
Dosage & Administration
- Dissolution of Gall stones: 8-12 mg/kg/day as single night time dose or in divided doses
- Primary Billiary Cirrhosis: 10-15 mg/kg/day in 2-4 divided doses
- Acute Viral Hepatitis: 600 mg/day
- Alcoholic Fatty Liver: 300 mg/day
- Primary Sclerosing Cholangitis: 25-30 mg/kg/day
- Non-Alcoholic Steato Hepatitis: 13-15 mg/kg/day
Interaction
Avoid use with drugs that increase bile cholesterol, concomitant administration with bile-acid binding drugs including antacids, charcoal, and cholestyramine
Contraindications
- Non-functioning gall-bladder
- Calcified and pigmented gallstones
- Inflammatory bowel disease
Side Effects
- Nausea
- Vomiting
- Diarrhoea
- Gallstone opacilication
- Pruritus
Pregnancy & Lactation
Pregnancy category B, no evidence of harm reported, effectively used for cholestasis of pregnancy during last trimester, no documented problems regarding breastfeeding
Precautions & Warnings
Use cautiously in those with liver disease
Therapeutic Class
Anti-gallstones drugs: Bile Acids
Storage Conditions
Store below 25°C, protect from light and moisture, keep out of reach of children