Starfil 50 mg (Tablet)
Unit Price: ৳ 35.00 (1 x 4: ৳ 140.00)
Strip Price: ৳ 140.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sildenafil citrate |
| Company | Benham pharmaceuticals ltd |
| Also available as |
Indications
- Treatment of erectile dysfunction in men
- Treatment of pulmonary arterial hypertension
Description
- Selective, reversible inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5)
- Requires sexual stimulation for effectiveness
Mechanism of Action
- Increase levels of cGMP in the corpus cavernosum
- Results in smooth muscle relaxation and inflow of blood into the penile tissues
Pharmacokinetics
- Mean absolute bioavailability of 41%
- Eliminated predominantly by hepatic metabolism
- Metabolized by cytochrome P450 3A4
Dosage & Administration
- Recommended starting dose of 50mg for erectile dysfunction
- Maximum recommended dosing frequency is once per day
- Recommended dose for pulmonary arterial hypertension is 20mg three times a day
Interaction
- Metabolism is mediated by cytochrome P450 isoforms 3A4 and 2C9
- Inhibitors of these isoenzymes may reduce clearance
Contraindications
- Hypersensitivity to any component
- Concomitant use of organic nitrates
Side Effects
- Cardiovascular events
- Digestive issues
- Hemic and Lymphatic disorders
- Musculoskeletal problems
- Nervous system complications
- Respiratory concerns
- Skin and Appendages reactions
- Special Senses abnormalities
- Urogenital problems
Pregnancy & Lactation
- Pregnancy category B
- No use in pregnant women
- No evidence of teratogenicity or embryotoxicity in animal studies
Precautions & Warnings
- Caution with alpha-blockers
- Consideration for patients with cardiovascular risk factors
- Sensitivity in patients with left ventricular outflow obstruction
- Caution in patients with certain conditions or recent medical events
Overdose Effects
- Adverse events similar to lower doses
- Standard supportive measures should be adopted
Therapeutic Class
- Drugs for Erectile Dysfunction
Storage Conditions
- Keep in a dry place
- Away from light and heat
- Keep out of the reach of children