Silvec 1% (Cream)
30 gm tube: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Drug international ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Structural changes in bacterial cell membrane
- Weakening of cell wall membrane
- Reduction of bacterial viability
- Prevention of bacterial cell proliferation
- Bacteriostatic action against sensitive organisms
- Approximately 10% absorption in adults
- 31.8 mg/L urinary sulfadiazine concentration in children with 13% body surface area burns
Dosage & Administration
- Cleansing of burn wounds
- Application once to twice daily
- Thickness of approximately 1/16 inches (1.5 mm)
- Reapplication as necessary
- Use of dressings if required
- Continued treatment until satisfactory healing or grafting readiness
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin in large area burns
- Possible increase in leukopenia incidence with co-administration of Cimetidine
Contraindications
- Hypersensitivity to the drug or its ingredients
- Use on pregnant women approaching or at term
- Use on premature infants or newborns during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Category B in pregnancy
- Use only if clearly justified in pregnant women approaching or at term
- Unknown excretion in human milk
- Consideration of discontinuing nursing or drug based on importance to mother
Precautions & Warnings
- Impaired hepatic and renal functions leading to drug accumulation
- Inactivation possibility of topical proteolytic enzymes
- Monitoring of serum sulfa concentrations in extensive burn wounds
- Careful monitoring of renal function and urine for sulfa crystals
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature below 30°C
- Away from light and moisture
- Out of the reach of children