Silverax 1% (Cream)
25 gm tube: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Healthcare pharmaceuticals ltd |
Indications
- Topical prophylaxis against bacterial colonization and infection in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds, other than burns
Pharmacology
- Mechanism of antibacterial action
- Structural changes in bacterial cell membrane
- Weakening of cell wall membrane
- Reduction in viability of sensitive strains
- Binding of silver moiety to bacterial cells
- Inhibition of bacterial cell proliferation
- Sulfadiazine moiety providing bacteriostatic action
- Absorption and excretion in adults
- Urinary sulfadiazine concentration in children with burns
Dosage & Administration
- Cleansing of burn wounds
- Application of Silver Sulfadiazine
- Frequency of application
- Thickness of application
- Reapplication as necessary
- Use of dressings if required
- Continuation of treatment until healing
- Withdrawal in case of adverse reactions
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Recommendation for monitoring blood levels
- Increased risk of leukopenia with co-administration of Cimetidine
Contraindications
- Hypersensitivity to Silver Sulfadiazine or other ingredients
- Use on pregnant women approaching or at term
- Use on premature or newborn infants in the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Use during pregnancy justified with caution
- Unknown excretion in human milk
- Consideration of drug importance versus nursing
Precautions & Warnings
- Monitoring of hepatic and renal functions
- Accumulation with decreased drug elimination
- Inactivation of topical proteolytic enzymes
- Monitoring serum sulfa concentrations
- Renal function and urine monitoring
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature and light considerations
- Protection from moisture
- Keep out of reach of children