Silzin 1% (Cream)
25 gm tube: ৳ 50.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Kemiko pharmaceuticals ltd |
Indications
- Topical prophylaxis against bacterial colonization in burn wounds
- Topical antibacterial management of contaminated or infection-prone wounds
Pharmacology
- Silver sulfadiazine's antibacterial action
- Structural changes in bacterial cell membrane
- Weakening of the cell wall membrane
- Binding of silver moiety to bacterial cells
- Prevention of bacterial cell proliferation
Dosage & Administration
- Application over burn wounds
- Daily application
- Thickness of application
- Use with dressings if necessary
- Continued treatment until healing occurs
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to ingredients
- Pregnant women approaching or at term
- Premature infants
- Newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy category B
- Consideration for nursing mothers
Precautions & Warnings
- Impaired hepatic and renal functions
- Possible inactivation of proteolytic enzymes
- Monitoring of serum sulfa concentrations
- Renal function monitoring
- Check for sulfa crystals in urine
Therapeutic Class
- Topical Antibiotic preparations
Storage Conditions
- Temperature below 30°C
- Protection from light and moisture
- Keep out of reach of children