Burnaid 1% (Cream)
25 gm tube: ৳ 40.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Silver sulfadiazine |
| Company | Kumudini pharma ltd |
Indications
- Topical prophylaxis against bacterial colonization in burn wounds
- Topical antibacterial management of contaminated wounds
- Infection-prone wounds management
Pharmacology
- Antibacterial action mechanism not fully elucidated
- Structural changes in bacterial cell membrane
- Weakening of cell wall membrane
- Reduced viability in sensitive strains
- Silver moiety binding to bacterial cells
- Prevention of bacterial cell proliferation
- Sulfadiazine moiety provides bacteriostatic action
- Approximately 10% absorption in adults
- 60-85% absorbed amount excreted in urine
- 31.8 mg/L urinary sulfadiazine concentration in children with 13% body surface area burns
Dosage & Administration
- Cleansing of burn wounds before application
- Application of Silver Sulfadiazine over burn wound
- Covering burn areas with Silver Sulfadiazine at all times
- Application once to twice daily with specified thickness
- Reapplication to removed areas
- Use of dressings if necessary
- Reapplication after hydrotherapy
- Continued treatment until satisfactory healing or grafting readiness
- No withdrawal from therapeutic regimen in case of infection possibility
Interaction
- Inactivation of enzymatic debriding agents
- Potentiation of oral hypoglycemic agents and phenytoin
- Increased incidence of leukopenia with cimetidine co-administration
Contraindications
- Hypersensitivity to ingredients
- Pregnant women approaching or at term
- Premature infants
- Newborn infants during the first 2 months of life
Side Effects
- Transient leukopenia
- Skin necrosis
- Erythema multiform
- Skin discoloration
- Burning sensation
- Rashes
- Interstitial nephritis
Pregnancy & Lactation
- Pregnancy Category B
- Use during pregnancy only if clearly justified
- Unknown excretion in human milk
- Decision-making regarding nursing and drug continuation
Precautions & Warnings
- Impaired hepatic and renal functions
- Accumulation risk with decreased drug elimination
- Inactivation of topical proteolytic enzymes
- Monitoring of serum sulfa concentrations in extensive burn wounds
- Careful renal function monitoring
- Urinary sulfa crystals check
Therapeutic Class
- Topical antibiotic preparations
Storage Conditions
- Keep below 30°C temperature
- Away from light and moisture
- Keep out of the reach of children