Vastin 10 mg (Tablet)

Title

• Vastin 10mg Tablet

Category

• Medicine
• Pharmaceutical
• Health

Description

• Vastin 10mg Tablet is indicated as an adjunct to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B (Apo-B) and triglycerides levels in various diseases, in conjunction with diet and other non-pharmacological measures.

Primary Use

• Reduction of total cholesterol and LDL cholesterol
• Treatment of mixed dyslipidemia
• Prevention of cardiovascular events
• Reduction of cardiac ischaemic events
• Hypercholesterolemia associated with diabetes mellitus or renal transplantation
• Adjunct to diet in familial hypercholesterolemia

Mode of Action

• Selective inhibitor of HMG-CoA reductase
• Lowers plasma cholesterol and lipoprotein levels
• Increases hepatic LDL receptors for enhanced uptake and catabolism of LDL

Absorption

• Rapidly absorbed after oral administration
• Maximum plasma concentrations occur within 1 to 2 hours

Distribution

• Mean volume of distribution is approximately 381 liters
• 98% bound to plasma proteins

Metabolism

• Extensively metabolized to ortho- and parahydroxylated derivatives and various beta-oxidation products
• In vitro studies suggest importance of metabolism by cytochrome P450 3A4

Excretion

• Eliminated primarily in bile following hepatic and/or extra-hepatic metabolism
• Mean plasma elimination half-life is approximately 14 hours

Dosage & Administration

• Recommended starting dose of 10 or 20 mg once daily
• Doses should be individualized according to recommended goal of therapy
• Can be administered as a single dose at any time of the day, with or without food
• Adjustments should be made at intervals of 4 weeks or more

Interactions

• Increased risk of myopathy with concurrent administration of certain drugs
• Plasma concentrations altered when coadministered with antacid, colestipol, digoxin, erythromycin, oral contraceptives, warfarin

Contraindications

• Hypersensitivity to any component of this medication
• Active liver disease or unexplained persistent elevations of serum transaminases
• History of serious adverse reaction to prior administration of HMG-CoA reductase inhibitors

Side Effects

• Most frequent side effects include constipation, flatulence, dyspepsia, abdominal pain
• Other side effects include infection, headache, back pain, rash, asthenia, arthralgia, myalgia

Pregnancy & Lactation

• Contraindicated during pregnancy
• Not known whether it's excreted in human milk
• Maternal treatment may reduce fetal levels of mevalonate
• Safety in pregnant women not established

Precautions & Warnings

• Liver function tests should be performed before initiation of treatment and periodically thereafter
• Discontinue therapy if markedly elevated CPK levels occur or myopathy is diagnosed or suspected

Use in Special Populations

• Plasma concentrations higher in healthy elderly subjects
• No clinically significant difference in LDL-C reduction between men and women
• Renal disease has no influence on plasma concentrations or LDL-C reduction
• Hemodialysis not expected to significantly enhance clearance

Overdose Effects

• Specific treatment not available
• Patient should be treated symptomatically and supportive measures instituted
• Liver function tests should be performed and serum CK levels monitored

Therapeutic Class

• Other Anti-anginal & Anti-ischaemic drugs
• Statins

Storage Conditions

• Keep in a dry place away from light and heat
• Keep out of the reach of children

Chemical Structure

• Molecular Formula: C33H35FN2O5
• Chemical Structure Image: Link to chemical structure image

Common Questions

• What is Vastin 10 mg Tablet?
• How should I take Vastin 10 mg Tablet?
• What are the uses of Vastin 10 mg Tablet?
• What are the Side Effects of Vastin 10 mg Tablet?
• What are the instructions for storage and disposal of Vastin 10 mg Tablet?
• Is Vastin 10 mg Tablet used for lowering cholesterol?
• Will taking Vastin 10 mg Tablet increase my risk of diabetes?
• For how long do I need to take Vastin 10 mg Tablet? Is it safe for long-term use?
• Does Vastin 10 mg Tablet cause weight loss?
• Can I stop taking Vastin 10 mg Tablet?
• Does Vastin 10 mg Tablet cause memory loss?
• Does Vastin 10 mg Tablet make you tired?
• Can Vastin 10 mg Tablet be prescribed to children?
• Is Vastin 10 mg Tablet a blood thinner?
• Quick Tips for taking Vastin 10 mg Tablet

Indications

• Indicated as an adjunct to diet to reduce elevated total cholesterol, LDL cholesterol, apolipoprotein B and triglycerides levels
• For various diseases when response to diet and other non-pharmacological measures is inadequate

Blood Test Monitoring

• Liver function tests should be performed before initiation of treatment and periodically thereafter

Associated Risks

• Increased risk of myopathy with concurrent administration of certain drugs
• Potential adverse reactions in pregnant women and during lactation

Maximum Dosage

• Maximum dosage of 80 mg once daily for adults

Molecular Weight

• Approximately 558.65 g/mol

Tolerability

• Generally well-tolerated

Bioavailability

• Approximately 14% for Atorvastatin (parent drug)
• Approximately 30% for systemic availability of HMG-CoA reductase inhibitory activity

Plasma Protein Binding

• 98% bound to plasma proteins

AUC Values

• AUC values for norethindrone and ethinyl estradiol increased by approximately 30% and 20% when coadministered with an oral contraceptive

Drug Food Interaction

• Can be taken with or without food

Pediatric Use

• Recommended starting dose of 10 mg/day for pediatric patients aged 10-17 years

Elderly Population

• Plasma concentrations are higher in elderly subjects compared to young adults

Hepatic Insufficiency

• Plasma concentrations are markedly increased in patients with chronic alcoholic liver disease

Special Populations

• Pharmacokinetic data not available for the pediatric population

Niacin Interaction

• Increased risk of myopathy with concurrent administration of niacin

Cyclosporine Interaction

• Increased risk of myopathy with concurrent administration of cyclosporine

Fibric Acid Derivatives Interaction

• Increased risk of myopathy with concurrent administration of fibric acid derivatives

Molecular Structure

• Chemical structure consists of C, H, F, N, and O atoms in specific proportions

Supportive Measures

• Supportive measures should be instituted for atorvastatin overdose

Elimination half-life

• Approximately 14 hours in humans

Potential Side Effects

• May include constipation, flatulence, dyspepsia, abdominal pain, infection, headache, back pain, rash, asthenia, arthralgia, myalgia

Preventive Use

• Prevention of heart attacks
• Prevention of cardiovascular events

Biochemical Pathway

• Selective inhibition of HMG-CoA reductase enzyme

Avoidable Interactions

• Avoid concurrent administration with drugs that increase the risk of myopathy

Disposition

• Primarily eliminated in bile following hepatic and/or extra-hepatic metabolism

Plasma Levels Monitoring

• Steady-state plasma digoxin concentrations increased by approximately 20% with coadministration of atorvastatin and digoxin

Known Allergies

• Hypersensitivity to any component of this medication

Anion-exchange Resin Use

• May be combined with anion-exchange resin in heterozygous familial hypercholesterolaemia

Selective Inhibition

• Selective inhibition of HMG-CoA reductase

Pediatric Dose Adjustment

• Recommended starting dose of 10 mg once daily for children aged 10-18 years

Severity of Adverse Effects

• Serious adverse reaction to prior administration of HMG-CoA reductase inhibitors reported

Dose Adjustment

• Dose should be adjusted according to response

Dose Range

• Dosage range of 10 to 80 mg once daily

Medication Planning

• After initiation, lipid levels should be analyzed within 2 to 4 weeks and dosage adjusted accordingly

Teratogenic Effects

• Rare reports of congenital anomalies following intrauterine exposure to HMG-CoA reductase inhibitors

Xenobiotic Metabolism

• Extensive metabolism to ortho- and parahydroxylated derivatives and various beta-oxidation products

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