Rythmosin 150 mg (Tablet)
Unit Price: ৳ 15.00 (3 x 10: ৳ 450.00)
Strip Price: ৳ 150.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Propafenone hydrochloride |
| Company | Unimed unihealth pharmaceuticals ltd |
Indications
- Treatment of paroxysmal atrial fibrillation/flutter (PAF)
- Treatment of paroxysmal supraventricular tachycardia (PSVT)
- Treatment of ventricular arrhythmias
Pharmacology
- Slows influx of sodium ions into cardiac muscle cells
- Decreases excitability of cells
- Selective for cells with a high rate
- Blocks normal cells more than class Ia or Ib
- Additional activity as a beta-adrenergic blocker
Dosage & Administration
- Individually titrated dose
- Initiate therapy with 150 mg every eight hours
- Dosage increase at minimum of 3 to 4 day intervals
- Maximum recommended dosage of 900 mg per day
Interaction
- Metabolized by CYP2D6, CYP1A2, and CYP3A4
- Inhibited by drugs such as desipramine, paroxetine, ritonavir
- Inhibits CYP2D6
- Potential drug interactions with desipramine, imipramine, haloperidol, venlafaxine
Contraindications
- Uncontrolled congestive heart failure
- Cardiogenic shock
- Sinoatrial, atrioventricular and intraventricular disorders of impulse generation and/or conduction
- Bradycardia
- Marked hypotension
- Bronchospastic disorders
- Electrolyte imbalance
- Known hypersensitivity to the drug
Side Effects
- Gastrointestinal adverse reactions
- Cardiovascular adverse reactions
- Central nervous system adverse reactions
- Change in taste
- Constipation
- Diarrhea
- Dizziness
- Drowsiness
- Dry mouth
- Nausea
- Tiredness
- Severe allergic reactions
Pregnancy & Lactation
- Pregnancy category C
- Limited data on use during pregnancy
- Potential excretion in human milk
- Potential for serious adverse reactions in nursing infants
Precautions & Warnings
- Caution in hepatic dysfunction
- Dose adjustment for impaired hepatic function
- Caution in renal dysfunction
- Exacerbation of myasthenia gravis reported
- Cautious use in pediatric patients
- Caution in geriatric patients
Use in Special Populations
- Safety and effectiveness in pediatric patients not established
- Cautious dose selection for elderly patients
Therapeutic Class
- Membrane stabilizing agent (Sodium channel blockers)
Storage Conditions
- Store at 25°C
- Store in a cool and dry place
- Protect from light
- Keep out of children’s reach