Agoxin 0.25 mg (Tablet)

Title

• Agoxin

Categories

• Medicine
• Healthcare

Description

• Agoxin is indicated for heart failure, atrial fibrillation with uncontrolled ventricular rate, acute left ventricular failure, chronic left ventricular failure, and congestive heart failure.

Indications

• Heart failure
• Atrial fibrillation with uncontrolled ventricular rate
• Acute left ventricular failure
• Chronic left ventricular failure
• Hypertensive valvular disease
• Ischaemic heart disease

Pharmacology

• Cardiac glycoside
• Positive inotropic activity
• Reduction in heart conductivity
• Direct action on vascular smooth muscle
• Indirect effects mediated by the autonomic nervous system
• Increase in vagal activity

Dosage & Administration

• Rapid digitalization: 1-1.5 mg in divided doses over 24 hours
• Less urgent digitalization: 250-500 micrograms daily
• Maintenance: 62.5-500 micrograms daily
• Usual range: 125-250 micrograms daily
• Usual range for elderly: 125-250 micrograms daily

Interactions

• Potassium-depleting diuretics
• Calcium administration
• Quinidine
• Verapamil
• Amiodarone
• Propafenone
• Indomethacin
• Itraconazole
• Alprazolam
• Spironolactone
• Erythromycin
• Clarithromycin
• Tetracycline
• Antacids
• Kaolinpectin
• Sulfasalazine
• Neomycin
• Penicillamine
• Calestipol
• Metoclopramide
• Rifampin

Contraindications

• Ventricular fibrillation
• Hypersensitivity to digoxin

Side Effects

• Anorexia
• Nausea
• Vomiting
• Diarrhoea
• Abdominal pain
• Visual disturbance
• Headache
• Fatigue
• Drowsiness
• Confusion
• Delirium
• Hallucination
• Depression
• Arrhythmia
• Heart block
• Intestinal ischaemia
• Gynaecomastia
• Thrombocytopenia

Pregnancy & Lactation

• Excreted in breast milk
• Concentration below plasma levels
• No hazard to breast-fed infant

Use in Special Populations

• Neonates
• Children
• The elderly

Therapeutic Class

• Positive Inotropic drugs

Storage Conditions

• Cool and dry place
• Keep out of reach of children

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