Sitalia M XR 50 mg+500 mg (Tablet (Extended Release))
Unit Price: ৳ 15.00 (3 x 4: ৳ 180.00)
Strip Price: ৳ 60.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Delta pharma ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for glycemic control in type 2 diabetes mellitus
- Not indicated for type 1 diabetes or diabetic ketoacidosis treatment
- Not studied in patients with a history of pancreatitis
Pharmacology
- Combines sitagliptin and metformin as antihyperglycemic agents
- Sitagliptin: DPP-4 inhibitor affecting incretin hormones
- Metformin: Decreases hepatic glucose production and increases peripheral glucose uptake
Dosage & Administration
- Individualized dosage based on patient's regimen and tolerability
- Initial combination therapy based on healthcare provider's discretion
- Starting dose and gradual escalation with meals to reduce GI side effects
Interaction
- Cationic drugs caution for renal tubular secretion
- Metformin may decrease phenprocoumon's anticoagulant effect
- Levothyroxine can reduce metformin's hypoglycemic effect
Contraindications
- Contradicted in patients with renal disease or dysfunction
- Acute or chronic metabolic acidosis including diabetic ketoacidosis
- History of serious hypersensitivity reaction to the tablet or sitagliptin
Side Effects
- Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
- Hypoglycemia reported in patients treated with insulin and metformin
- Nasopharyngitis reported in patients treated with sitagliptin monotherapy
Pregnancy & Lactation
- Pregnancy Category B - safety not well-studied in pregnant women
- Caution advised when administered to a nursing woman
Precautions & Warnings
- Lactic acidosis risk with conditions like sepsis, dehydration, and renal impairment
- Hepatic disease caution, monitor renal and pancreatic function
- Potential decrease in vitamin B12 serum levels with long-term use
Overdose Effects
- Supportive measures for overdose, consider hemodialysis for metformin
- Pancreatitis may occur in the context of a metformin overdose
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
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