Sucosit M 50 mg+1000 mg (Tablet)
Unit Price: ৳ 16.00 (3 x 6: ৳ 288.00)
Strip Price: ৳ 96.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Globe pharmaceuticals ltd |
Title and Categories
- Sitagliptin and Metformin Tablet
- Oral hypoglycemic preparations
Dimensions
- Film-coated tablet
- Extended-release tablet
Color Options
- Not applicable
Functions
- Improves glycemic control in adults with type 2 diabetes mellitus
- Slows the inactivation of incretin hormones
- Increases insulin release and decreases glucagon levels in a glucose-dependent manner
- Decreases hepatic glucose production
- Decreases intestinal absorption of glucose
- Increases peripheral glucose uptake and utilization
- Reduces hepatic glucose production
- Lowers glucagon secretion from pancreatic alpha cells
Materials
- Sitagliptin
- Metformin HCl
Technical Specifications
- Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
- Dosage individualized based on patient's current regimen, effectiveness, and tolerability
- Should generally be given twice daily with meals
- Dosage escalation to reduce gastrointestinal side effects
- Recommended starting doses for different patient scenarios
- Administered once daily with a meal for extended-release tablet
Design Elements
- Combines two antihyperglycemic agents with complementary mechanisms of action
Usability Features
- Individualized dosage based on patient's current regimen
- Gradual dose escalation to reduce gastrointestinal side effects
- Option for extended-release tablet for once-daily administration
Interactions
- Cationic drugs eliminated by renal tubular secretion: Use with caution
- Metformin may decrease the anticoagulant effect of phenprocoumon
- Levothyroxine can reduce the hypoglycemic effect of metformin
Contraindications
- Renal disease or renal dysfunction
- Acute or chronic metabolic acidosis
- History of a serious hypersensitivity reaction
- Undergoing radiologic studies involving intravascular administration of iodinated contrast materials
Side Effects
- Diarrhea
- Upper respiratory tract infection
- Headache
- Hypoglycemia
- Nasopharyngitis
- Nausea/vomiting
- Flatulence
- Abdominal discomfort
- Indigestion
- Asthenia
Pregnancy & Lactation
- Pregnancy Category B - Use during pregnancy only if clearly needed
- Caution advised when administered to a nursing woman
Precautions & Warnings
- Risk of lactic acidosis
- Decrease in vitamin B12 serum levels
- Regular monitoring of thyroid-stimulating hormone (TSH) levels
- Assessing renal function before initiating the tablet
- Monitoring for evidence of ketoacidosis or lactic acidosis
- Lower dose of insulin secretagogue or insulin when used in combination
- Postmarketing reports of serious allergic and hypersensitivity reactions
Overdose Effects
- Usual supportive measures for Sitagliptin overdose
- Modestly dialyzable Sitagliptin
- Overdose of metformin hydrochloride
- Metformin is dialyzable
- Hemodialysis may be useful for removal of accumulated drug
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep the medicines in a safe place, out of the reach of children
- To be dispensed only on the prescription of a registered physician
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