Silinor-M 50 mg+1000 mg (Tablet)

Unit Price: ৳ 22.00 (3 x 8: ৳ 528.00)
Strip Price: ৳ 176.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Healthcare pharmaceuticals ltd
Also available as
Silinor m 50 mg tablet

Product Title

  • Sitagliptin Phosphate Monohydrate INN/Metformin Hydrochloride BP Tablet

Categories

  • Medicine
  • Diabetes Management
  • Oral Hypoglycemic Preparations

Description

  • Indicated as an adjunct to diet and exercise for improving glycemic control in adults with type 2 diabetes mellitus when treatment with both sitagliptin and metformin is appropriate
  • Combines two antihyperglycemic agents with complementary mechanisms of action to improve glycemic control in patients with type 2 diabetes
  • Dosage should be individualized based on the patient's current regimen, effectiveness, and tolerability while not exceeding the maximum recommended daily dose

Color Options

  • None

Dimensions

  • Standard tablet size

Functions

  • Improves glycemic control
  • Decreases hepatic glucose production
  • Decreases intestinal absorption of glucose
  • Increases peripheral glucose uptake and utilization

Materials

  • Sitagliptin Phosphate Monohydrate
  • Metformin Hydrochloride BP

Technical Specifications

  • Combination of Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, and Metformin HCl, a biguanide class member

Design Elements

  • Film-coated tablet
  • Extended-release tablet

Usability Features

  • Individualized dosage
  • Gradual dose escalation to reduce gastrointestinal side effects
  • Twice daily administration with meals
  • May be administered once daily with a meal in the evening

Interaction

  • Cationic drugs eliminated by renal tubular secretion should be used with caution
  • Metformin may decrease the anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce the hypoglycemic effect of metformin

Contraindications

  • Renal disease or renal dysfunction
  • Acute or chronic metabolic acidosis
  • History of a serious hypersensitivity reaction to the tablet or sitagliptin

Side Effects

  • Diarrhea
  • Upper respiratory tract infection
  • Headache
  • Hypoglycemia
  • Nasopharyngitis
  • Nausea/vomiting
  • Flatulence
  • Abdominal discomfort
  • Indigestion
  • Asthenia

Pregnancy & Lactation

  • Category B for pregnancy
  • Caution advised when administered to a nursing woman

Precautions & Warnings

  • Lactic acidosis risk
  • Regular monitoring of thyroid-stimulating hormone (TSH) levels
  • Monitoring of vitamin B12 level
  • Assessment of renal function and verification as normal before and during usage
  • Acute pancreatitis risk
  • Monitoring of hematologic parameters
  • Caution against excessive alcohol intake
  • Evaluation for evidence of ketoacidosis or lactic acidosis

Overdose Effects

  • Sitagliptin is modestly dialyzable
  • Prolonged hemodialysis may be considered if clinically appropriate
  • Metformin is dialyzable with a clearance of up to 170 mL/min
  • Hemodialysis may be useful for removal of accumulated drug from patients in whom metformin overdosage is suspected

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Do not use later than the date of expiry
  • To be dispensed only on the prescription of a registered physician

Related Brands