Sitagil M 50 mg+1000 mg (Tablet (Extended Release))

Unit Price: ৳ 18.00 (3 x 6: ৳ 324.00)
Strip Price: ৳ 108.00

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Incepta pharmaceuticals ltd
Also available as
Sitagil m 50 mg tablet Sitagil m 100 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Improves glycemic control in adults
  • Appropriate for combination therapy with sitagliptin and metformin
  • Not for type 1 diabetes or diabetic ketoacidosis

Pharmacology

  • Combines sitagliptin and metformin for antihyperglycemic action
  • Sitagliptin is a DPP-4 inhibitor
  • Metformin HCl is a biguanide class member
  • Mechanism of action involves incretin hormone regulation

Dosage & Administration

  • Individualized dosage based on patient's regimen
  • Maximum recommended daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Initial combination therapy or maintenance should be individualized
  • Gradual dose escalation with meals to reduce GI side effects

Interaction

  • Caution with cationic drugs eliminated by renal tubular secretion
  • Metformin may decrease anticoagulant effect of phenprocoumon
  • Levothyroxine can reduce hypoglycemic effect of metformin

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction to the tablet or sitagliptin
  • Discontinue temporarily for patients undergoing radiologic studies with iodinated contrast materials

Side Effects

  • Common adverse reactions include diarrhea, upper respiratory tract infection, and headache
  • Hypoglycemia reported in combination with sulfonylurea and insulin
  • Nasopharyngitis reported in sitagliptin monotherapy
  • Common adverse reactions due to metformin initiation include diarrhea, nausea/vomiting, and headache

Pregnancy & Lactation

  • Pregnancy Category B
  • Safety in pregnant women not well-studied
  • Caution advised during nursing

Precautions & Warnings

  • Risk of lactic acidosis with metformin accumulation
  • Monitor TSH levels in patients with hypothyroidism
  • Long-term treatment associated with decreased vitamin B12 levels

Overdose Effects

  • Usual supportive measures for sitagliptin overdose
  • Metformin overdose may require hemodialysis for removal

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Dispense only on the prescription of a registered physician

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