Centoxin 0.25 mg (Tablet)

Unit Price: ৳ 1.09 (5 x 10: ৳ 54.50)
Strip Price: ৳ 10.90

Medicine Details

Category Details
Generic Digoxin
Company Opsonin pharma ltd
Also available as
Centoxin 025 mg oral solution

Title

  • Centoxin

Categories

  • Cardiac Medication
  • Positive Inotropic Drugs

Description

  • Used in the management of heart failure
  • Indicated in atrial fibrillation with an uncontrolled ventricular rate
  • Treatment for acute/left ventricular failure
  • Suitable for chronic/left ventricular failure and congestive heart failure especially caused by hypertensive valvular disease or ischemic heart disease

Indications

  • Heart failure
  • Atrial fibrillation with uncontrolled ventricular rate
  • Acute left ventricular failure
  • Chronic left ventricular failure
  • Congestive heart failure
  • Hypertensive valvular disease
  • Ischemic heart disease

Pharmacology

  • Positive inotropic activity
  • Reduction in conductivity of the heart
  • Direct action on vascular smooth muscle
  • Indirect effects mediated primarily by the autonomic nervous system
  • Increase in vagal activity

Dosage & Administration

  • Rapid digitalization: 1-1.5 mg in divided doses over 24 hours
  • Less urgent digitalization: 250-500 micrograms daily
  • Maintenance: 62.5-500 micrograms daily
  • Usual range: 125-250 micrograms daily
  • Appropriate dose for the elderly

Interactions

  • Potassium-depleting diuretics
  • Calcium
  • Quinidine
  • Verapamil
  • Amiodarone
  • Propafenone
  • Indomethacin
  • Itraconazole
  • Alprazolam
  • Spironolactone
  • Erythromycin
  • Clarithromycin
  • Tetracycline
  • Antacids
  • Kaolinpectin
  • Sulfasalazine
  • Neomycin
  • Penicillamine
  • Calestipol
  • Metoclopramide
  • Rifampin

Contraindications

  • Ventricular fibrillation
  • Hypersensitivity to digoxin or other digitalis preparation

Side Effects

  • Anorexia
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal pain
  • Visual disturbance
  • Headache
  • Fatigue
  • Drowsiness
  • Confusion
  • Delirium
  • Hallucination
  • Depression
  • Arrhythmia
  • Heart block
  • Intestinal ischaemia
  • Gynaecomastia on long term use
  • Thrombocytopenia

Pregnancy & Lactation

  • Excreted in breast milk in low concentrations

Use in Special Populations

  • Neonates: safe use
  • Children: safe use
  • The elderly: require lower maintenance dose

Therapeutic Class

  • Positive Inotropic drugs

Storage Conditions

  • Cool and dry place
  • Keep out of reach of children

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