Radiglip-M 50 mg+500 mg (Tablet (Extended Release))
Unit Price: ৳ 20.00 (3 x 6: ৳ 360.00)
Strip Price: ৳ 120.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Radiant pharmaceuticals ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Improves glycemic control
Pharmacology
- Combines sitagliptin and metformin
- DPP-4 inhibitor
- Biguanide class member
- Incretin hormone regulation
- GLP-1 and GIP effects
- Decreases hepatic glucose production
- Increases peripheral glucose uptake
Dosage & Administration
- Individualized dosage
- Maximum recommended daily dose
- Twice-daily administration with meals
- Gradual dose escalation
- Safety and efficacy not studied with other antihyperglycemic agents
Interaction
- Cationic drugs caution
- Impact on phenprocoumon anticoagulant effect
- Levothyroxine interference with hypoglycemic effect of metformin
Contraindications
- Renal disease or dysfunction
- Metabolic acidosis
- Hypersensitivity reaction
- Radiologic studies with iodinated contrast materials
Side Effects
- Common adverse reactions
- Hypoglycemia
- Nasopharyngitis
- Diarrhea
- Nausea/vomiting
- Headache
- Fatulence
- Abdominal discomfort
Pregnancy & Lactation
- Pregnancy category B
- Caution in nursing women
Precautions & Warnings
- Risk of lactic acidosis
- Monitoring of TSH levels and vitamin B12
- Hepatic disease caution
- Renal function assessment
- Acute pancreatitis risk
- Hematologic parameter monitoring
- Allergic and hypersensitivity reactions
- Macrovascular risk reduction not clinically established
Overdose Effects
- Usual supportive measures for sitagliptin overdose
- Dialyzable properties of sitagliptin
- Potential usefulness of hemodialysis for metformin overdose
- Pancreatitis risk with metformin overdose
Therapeutic Class
- Combination oral hypoglycemic preparations
Storage Conditions
- Store below 25°C
- Dry place away from light
- Dispense only on prescription