SB-Metsita 50 mg+500 mg (Tablet)
Unit Price: ৳ 20.00 (20's pack: ৳ 400.00)
Medicine Details
| Category | Details |
|---|---|
| Generic | Sitagliptin metformin hydrochloride |
| Company | Sunman birdem pharma ltd |
| Also available as |
Indications
- Adjunct to diet and exercise for type 2 diabetes mellitus
- Improves glycemic control
- Not suitable for type 1 diabetes or diabetic ketoacidosis treatment
Pharmacology
- Combines sitagliptin and metformin HCl
- Mechanisms of action for glycemic control
- Inhibition of DPP-4 enzyme
- Regulation of glucose homeostasis
Dosage & Administration
- Individualized dosage based on regimen, effectiveness, and tolerability
- Maximum daily dose of 100 mg sitagliptin and 2000 mg metformin
- Initial combination therapy
- Gradual dose escalation with meals
Interaction
- Cationic drugs caution
- Interaction with phenprocoumon and levothyroxine
Contraindications
- Renal disease or dysfunction
- Acute or chronic metabolic acidosis
- History of serious hypersensitivity reaction
- Contradicted with certain radiologic studies
Side Effects
- Common adverse reactions
- Hypoglycemia with different combinations
- Nasopharyngitis, diarrhea, and headache
- Initiation of metformin therapy adverse reactions
Pregnancy & Lactation
- Category B for pregnancy
- Caution for nursing women
Precautions & Warnings
- Lactic Acidosis risk factors and symptoms
- Thyroid-stimulating hormone (TSH) monitoring
- Decrease in vitamin B12 serum levels
- Hepatic disease caution
- Assessment of renal function
- Acute pancreatitis caution
- Evaluation during increased stress or illness
- Allergic and hypersensitivity reaction monitoring
- No clinical studies for macrovascular risk reduction
Overdose Effects
- Supportive measures for sitagliptin overdose
- Modestly dialyzable sitagliptin
- Dialyzable metformin with clearance up to 170 mL/min
Therapeutic Class
- Combination Oral hypoglycemic preparations
Storage Conditions
- Store below 25°C in a dry place away from light
- Keep out of the reach of children
- Dispensed only on the prescription of a registered physician