SB-Metsita 50 mg+500 mg (Tablet)

Unit Price: ৳ 20.00 (20's pack: ৳ 400.00)

Medicine Details

Category Details
Generic Sitagliptin metformin hydrochloride
Company Sunman birdem pharma ltd
Also available as
Sb metsita 50 mg tablet

Indications

  • Adjunct to diet and exercise for type 2 diabetes mellitus
  • Improves glycemic control
  • Not suitable for type 1 diabetes or diabetic ketoacidosis treatment

Pharmacology

  • Combines sitagliptin and metformin HCl
  • Mechanisms of action for glycemic control
  • Inhibition of DPP-4 enzyme
  • Regulation of glucose homeostasis

Dosage & Administration

  • Individualized dosage based on regimen, effectiveness, and tolerability
  • Maximum daily dose of 100 mg sitagliptin and 2000 mg metformin
  • Initial combination therapy
  • Gradual dose escalation with meals

Interaction

  • Cationic drugs caution
  • Interaction with phenprocoumon and levothyroxine

Contraindications

  • Renal disease or dysfunction
  • Acute or chronic metabolic acidosis
  • History of serious hypersensitivity reaction
  • Contradicted with certain radiologic studies

Side Effects

  • Common adverse reactions
  • Hypoglycemia with different combinations
  • Nasopharyngitis, diarrhea, and headache
  • Initiation of metformin therapy adverse reactions

Pregnancy & Lactation

  • Category B for pregnancy
  • Caution for nursing women

Precautions & Warnings

  • Lactic Acidosis risk factors and symptoms
  • Thyroid-stimulating hormone (TSH) monitoring
  • Decrease in vitamin B12 serum levels
  • Hepatic disease caution
  • Assessment of renal function
  • Acute pancreatitis caution
  • Evaluation during increased stress or illness
  • Allergic and hypersensitivity reaction monitoring
  • No clinical studies for macrovascular risk reduction

Overdose Effects

  • Supportive measures for sitagliptin overdose
  • Modestly dialyzable sitagliptin
  • Dialyzable metformin with clearance up to 170 mL/min

Therapeutic Class

  • Combination Oral hypoglycemic preparations

Storage Conditions

  • Store below 25°C in a dry place away from light
  • Keep out of the reach of children
  • Dispensed only on the prescription of a registered physician

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