Clonipres 0.1 mg (Tablet)

Unit Price: ৳ 10.00 (6 x 10: ৳ 600.00)

Strip Price: ৳ 100.00

Medicine Details

Category	Details
Generic	Clonidine hydrochloride
Company	Navana pharmaceuticals ltd
Also available as	Clonipres er 01 mg tablet

Indications

Anxiety
Cancer pain
Generalized anxiety disorder
Hypertension
Hypertensive crisis
Menopausal flushing
Migraine
Panic disorder
Severe anxiety disorders
Social anxiety disorder

Pharmacology

Clonidine stimulates α2-adrenoceptors in the brain stem resulting in reduced sympathetic outflow from the CNS, a decrease in peripheral resistance, heart rate, BP, and renal vascular resistance.

Dosage & Administration

Adults:
- Initial Dose: 0.1 mg tablet twice daily (morning and bedtime)
- Maintenance Dose: Further increments of 0.1 mg per day may be made at weekly intervals if necessary until the desired response is achieved
Elderly Patients: May benefit from a lower initial dose
Therapeutic Doses: Most commonly ranged from 0.2 mg to 0.6 mg per day given in divided doses
Maximum Effective Daily Dose: 2.4 mg

Interaction

Increased hypotensive effect with other antihypertensives e.g. diuretics, β-blockers, vasodilators, Ca antagonists, ACE inhibitors
Reduced antihypertensive effect and induced orthostatic hypotension with TCAs or neuroleptics with α-receptor blocking properties
Reduced therapeutic effect with NSAIDs

Contraindications

Severe bradyarrhythmia secondary to 2nd- or 3rd-degree AV block or sick sinus syndrome

Side Effects

Headache
Dizziness
Drowsiness
Dry mouth
Constipation
Depression
Anxiety
Nausea
Fatigue
Anorexia
Parotid pain
Paraesthesia
Delusional perception
Sleep disturbances
Vivid dreams
Impotence and loss of libido
Urinary retention or incontinence
Orthostatic hypotension
Itching or burning sensations in the eye
Accommodation disorder
Decreased lacrimation
Fluid retention
Pruritus and rashes (transdermal)
Bradycardia
Other ECG disturbances
Heart failure
Hallucinations
Cramp
Raynaud's syndrome
Gynaecomastia
Transient abnormalities in LFTs

Pregnancy & Lactation

Category C: Drugs should be given only if the potential benefit justifies the potential risk to the fetus.

Precautions & Warnings

Patients with cerebrovascular disease
Ischaemic heart disease including MI
Occlusive peripheral vascular disorders (e.g. Raynaud's disease)
History of depression
Avoid abrupt withdrawal
Renal impairment
Pregnancy and lactation

Use in Special Populations

Renal Impairment: Patients may benefit from a lower initial dose. Patients should be carefully monitored.

Overdose Effects

Symptoms:
- Lethargy
- Pupillary constriction
- Hypotension
- Hypothermia
- Bradycardia
- Decreased or absent reflexes
- Irritability
- Miosis
- Weakness
- Somnolence (including coma)
- Resp depression (including apnoea)
Management: Perform gastric lavage following recent ingestion or admin activated charcoal and/or a cathartic. Supportive treatment may include admin of atropine sulfate for symptomatic bradycardia; IV fluids and/or inotropic sympathomimetic agents for hypotension; vasodilators for HTN. Naloxone may be used as adjunct for clonidine-induced resp depression, hypotension and/or coma.