Epival Chrono 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.00 (5 x 10: ৳ 600.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Sodium valproate
Company Albion laboratories limited
Also available as
Epival chrono 200 mg tablet Epival chrono 300 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet contains 200 mg
  • Sodium Valproate syrup contains 200 mg/5 ml
  • Sodium Valproate controlled release 200 tablet contains 200 mg (133.2 mg Sodium Valproate BP + 58 mg Valproic acid BP)
  • Sodium Valproate controlled release 300 tablet contains 300 mg (199.8 mg Sodium Valproate BP + 87 mg Valproic acid BP)
  • Sodium Valproate controlled release 500 tablet contains 500 mg (333 mg Sodium Valproate BP + 145 mg Valproic acid BP)
  • Sodium Valproate injection contains 500 mg in 5 ml

Pharmacology

  • Anti-epileptic activity against a variety of seizures
  • Increase in brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration for epilepsy in adults, children over 20 kg, and children up to 20 kg
  • Dosage for febrile convulsion, bipolar disorder, and prophylaxis of migraine
  • Injectable administration for adults and children

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common: anorexia, nausea, vomiting
  • CNS effects: sedation, ataxia, tremor
  • Other occasional effects: rash, alopecia, stimulation of appetite
  • Hepatic effects: elevation of liver enzymes, fulminate hepatitis
  • Special risks for children below 2 years and those on multiple antiepileptic agents

Pregnancy & Lactation

  • Crosses the placenta, associated with neural tube defects
  • Excreted in breast milk, little risk to the child

Precautions & Warnings

  • Monitoring of liver functions before and during therapy
  • Ensuring no undue potential for bleeding before major surgery
  • Care in renal impairment, pregnancy, breast-feeding, systemic lupus erythematosus
  • Partial elimination in urine as a ketone metabolite, leading to false urine ketone test interpretation
  • Avoidance of sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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