Proval CR 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.00 (5 x 4: ৳ 240.00)
Strip Price: ৳ 48.00

Medicine Details

Category Details
Generic Sodium valproate
Company General pharmaceuticals ltd
Also available as
Proval cr 200 mg tablet Proval 200 mg syrup Proval cr 300 mg tablet Proval 200 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Bipolar disorder treatment
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Migraine prophylaxis

Composition

  • Sodium Valproate tablet 200mg
  • Sodium Valproate syrup 200mg
  • Sodium Valproate controlled release 200 tablet
  • Sodium Valproate controlled release 300 tablet
  • Sodium Valproate controlled release 500 tablet
  • Sodium Valproate injection 500mg

Pharmacology

  • Anti-epileptic activity against a variety of seizures
  • Increase in brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral and injectable administration
  • Different dosages for adults and children
  • For epilepsy, bipolar disorder, prophylaxis of migraine

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Known hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Anorexia, nausea, vomiting
  • Effects on CNS including sedation, ataxia, tremor
  • Rash, alopecia, stimulation of appetite
  • Elevation of liver enzymes in plasma
  • Fulminate hepatitis (rare)
  • Hepatic injury, acute pancreatitis, hyperammonemia

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn
  • Excreted in breast milk

Precautions & Warnings

  • Monitoring of liver functions
  • No undue potential for bleeding
  • Care in renal impairment, pregnancy, breast-feeding, systemic lupus erythematosus
  • False interpretation of urine ketone test
  • Sudden withdrawal of therapy should be avoided

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light and out of the reach of children

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