Convules CR 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.00 (3 x 10: ৳ 360.00)
Strip Price: ৳ 120.00

Medicine Details

Category Details
Generic Sodium valproate
Company Opsonin pharma ltd
Also available as
Convules 200 mg syrup Convules cr 200 mg tablet Convules cr 300 mg tablet

Indications

  • Treatment of all types of epilepsy
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet - 200 mg
  • Sodium Valproate syrup - 200 mg/5ml
  • Sodium Valproate controlled release 200 tablet - 200 mg (Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg)
  • Sodium Valproate controlled release 300 tablet - 300 mg (Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg)
  • Sodium Valproate controlled release 500 tablet - 500 mg (Sodium Valproate BP 333 mg & Valproic acid BP 145 mg)
  • Sodium Valproate injection - 500 mg/5ml

Pharmacology

  • Endowed with anti-epileptic activity against a variety of seizures
  • Mechanism of action related to increasing brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Adult dosage: Initially 600 mg daily, increasing by 200 mg/day at 3-day intervals to a maximum of 2.5 g daily
  • Children dosage: Varies by weight
  • Injection dosage: Varies by body weight

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interaction with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Anorexia
  • Nausea
  • Vomiting
  • Sedation
  • Ataxia
  • Tremor
  • Rash
  • Alopecia
  • Elevation of liver enzymes
  • Hepatic injury
  • Acute pancreatitis
  • Hyperammonemia

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn
  • Excreted in breast milk

Precautions & Warnings

  • Monitoring of liver functions
  • No undue potential for bleeding
  • Caution in renal impairment, pregnancy, and breast-feeding
  • Partial elimination in urine as a ketone metabolite
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of the reach of children

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