Valoate CR 300 mg (Tablet (Controlled Release))

Unit Price: ৳ 8.03 (5 x 10: ৳ 401.50)
Strip Price: ৳ 80.30

Medicine Details

Category Details
Generic Sodium valproate
Company Square pharmaceuticals plc
Also available as
Valoate 200 mg syrup Valoate cr 200 mg tablet Valoate cr 500 mg tablet

Title

  • Valoate CR Vaiproate

Categories

  • Medicine
  • Pharmaceutical

Description

  • A medication used for the treatment of epilepsy, bipolar disorder, and prophylaxis of migraine
  • Available in different forms such as tablets, syrup, controlled-release tablets, and injection

Indications

  • Treatment of all types of epilepsy including partial, absence, generalized tonic-clonic, myoclonic, atonic seizures
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine

Composition

  • Sodium Valproate tablet containing 200 mg of Sodium Valproate BP
  • Sodium Valproate syrup containing 200 mg of Sodium Valproate BP
  • Sodium Valproate controlled release tablets in 200mg, 300mg, and 500mg strengths
  • Sodium Valproate injection containing Sodium Valproate BP equivalent to 500 mg of Valproic Acid

Mode of Action

  • Has anti-epileptic activity against various seizures
  • Increases brain levels of gamma-aminobutyric acid (GABA)

Dosage and Administration

  • Oral tablets given once or twice daily, syrup in divided doses
  • Dosage varies for different conditions and age groups
  • Injection given via slow intravenous injection or infusion

Interaction

  • Acts as a non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy and in women of childbearing potential

Side Effects

  • Common side effects include anorexia, nausea, and vomiting
  • Effects on CNS include sedation, ataxia, and tremor
  • Rare cases of rash, alopecia, and appetite stimulation
  • May elevate liver enzymes and cause fulminate hepatitis
  • Prone to hepatic injury, acute pancreatitis, and hyperammonemia in specific patient groups

Pregnancy and Lactation

  • Crosses the placenta and associated with neural tube defects in newborns
  • Excreted in breast milk with no apparent risk to the child

Precautions and Warnings

  • Monitor liver functions before and during therapy
  • Ensure no potential for bleeding before major surgery
  • Use with caution in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • May lead to false interpretation of urine ketone test
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drugs

Storage Conditions

  • Do not store above 30°C
  • Store away from light and out of the reach of children

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