Valoate CR 500 mg (Tablet (Controlled Release))

Unit Price: ৳ 12.03 (3 x 10: ৳ 360.90)
Strip Price: ৳ 120.30

Medicine Details

Category Details
Generic Sodium valproate
Company Square pharmaceuticals plc
Also available as
Valoate 200 mg syrup Valoate cr 200 mg tablet Valoate cr 300 mg tablet

Indications

  • Treatment of epilepsy
  • Treatment of bipolar disorder
  • Prophylaxis of migraine
  • Prophylaxis of febrile convulsion
  • Prophylaxis of post-traumatic epilepsy

Composition

  • Enteric-coated tablet
  • Syrup
  • Controlled release tablet
  • Injection
  • Contains Sodium Valproate BP 200 mg
  • Each 5 ml syrup contains Sodium Valproate BP 200 mg
  • Controlled release tablet contains Sodium Valproate 200 mg as Sodium Valproate BP 133.2 mg & Valproic acid BP 58 mg
  • Controlled release tablet contains Sodium Valproate 300 mg as Sodium Valproate BP 199.8 mg & Valproic acid BP 87 mg
  • Controlled release tablet contains Sodium Valproate 500 mg as Sodium Valproate BP 333 mg & Valproic acid BP 145 mg
  • Injectable solution contains Sodium Valproate BP eqv. to Valproic Acid 500 mg

Pharmacology

  • Anti-epileptic activity
  • Mechanism not fully established
  • Suggested increase in brain levels of gamma-aminobutyric acid (GABA)

Dosage & Administration

  • Oral administration
  • Dosage adjusted based on age and weight
  • Initial dosage for adults, children over 20 kg, and children up to 20 kg
  • Maintenance dosage for epilepsy, bipolar disorder, and prophylaxis of migraine
  • Injection for adults and children
  • Different maximum dosages for adults and children
  • Slow intravenous injection over 3-5 minutes for adults
  • Intravenous injection or infusion for children

Interaction

  • Non-specific inhibitor of drug metabolism
  • Significant interactions with Phenobarbital, Phenytoin, Warfarin, Aspirin

Contraindications

  • Hypersensitivity to the drug
  • Liver dysfunction
  • Restricted use during pregnancy
  • Restricted use in women of childbearing potential

Side Effects

  • Common: anorexia, nausea, vomiting
  • Effects on CNS: sedation, ataxia, tremor
  • Effects on hepatic function: elevation of liver enzymes, fulminate hepatitis
  • Other symptoms: rash, alopecia, stimulation of appetite
  • More prone in children below 2 years with other medical conditions and those being treated with multiple antiepileptic agents

Pregnancy & Lactation

  • Crosses the placenta
  • Associated with neural tube defects in newborn
  • Excreted in breast milk
  • Offer serum a-fetoprotein estimation to pregnant women treated with Sodium Valproate
  • Probable low risk when breastfeeding

Precautions & Warnings

  • Monitor liver functions before and during first 6 months of therapy
  • Ensure no undue potential for bleeding before starting and before major surgery
  • Take care in renal impairment, pregnancy, breast-feeding, and systemic lupus erythematosus
  • Partially eliminated in urine as a ketone metabolite
  • Avoid sudden withdrawal of therapy

Therapeutic Class

  • Primary anti-epileptic drug

Storage Conditions

  • Do not store above 30°C
  • Keep away from light
  • Keep out of reach of children

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