Sofomax 400 mg (Tablet)
Unit Price: ৳ 700.00 (1 x 7: ৳ 4,900.00)
Strip Price: ৳ 4,900.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sofosbuvir |
| Company | Aci limited |
Indications
- Treatment of chronic hepatitis C infection
- Combination antiviral treatment
- HCV genotype 1, 2, 3, 4 infection
- Hepatocellular carcinoma meeting Milan criteria
- HCV/HIV-1 co-infection
Pharmacology
- Inhibition of HCV NS5B polymerase
- Chain terminator
- Binding to Mg2+ ions
- Prevention of HCV viral replication
Dosage & Administration
- 400 mg tablet once daily
- With or without food
- Combination therapy with Ribavirin or Pegylated Interferon
- Different regimens for different genotypes
Interaction
- Reduced effect with P-gp inducers
- Potential bradycardia with amiodarone co-administration
Contraindications
- Contraindicated in pregnant women and men with pregnant partners
- Applicable contraindications for combination therapies
Side Effects
- Fatigue
- Headache
- Nausea
- Insomnia
- Anemia
- Pruritus
- Rash
- Chills
- Diarrhea
Pregnancy & Lactation
- Pregnancy Category B
- No well-controlled studies in pregnant women
- Unknown presence in human breast milk
Precautions & Warnings
- Risk of bradycardia with amiodarone co-administration
- Cardiac monitoring recommended
- Alternative treatment options
Use in Special Populations
- No established safety and effectiveness in children below 18 years
- Response rates in subjects over 65 years similar to younger subjects
Overdose Effects
- Highest dose is a single dose of 1200 mg
- No specific antidote available
- Supportive measures and vital sign monitoring
Therapeutic Class
- Hepatic viral infections (Hepatitis C)
Storage Conditions
- Keep out of reach of children
- Store in a cool and dry place
- Protect from light