Panovir 400 mg+100 mg (Tablet)
Unit Price: ৳ 1,000.00 (1 x 6: ৳ 6,000.00)
Strip Price: ৳ 6,000.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Sofosbuvir velpatasvir |
| Company | Incepta pharmaceuticals ltd |
Indications
- treatment of chronic HCV genotype 1-6 infection
- for patients with or without cirrhosis
- for pediatric patients 3 years and older
Pharmacology
- inhibitor of HCV NS5B RNA-dependent RNA polymerase
- required for viral replication
- inhibitor of HCV NS5A protein
- resistance selection in cell culture
- cardiac electrophysiology effect
- metabolism of active uridine analog triphosphate
Dosage & Administration
- recommended treatment regimen and duration
- recommended dosage in adults and pediatric patients
- dosage for HCV/HIV-1 coinfected patients
- dosage adjustments based on weight
- testing prior to initiation of therapy
Interaction
- effects on drug transporters P-gp and BCRP
- metabolic turnover of Velpatasvir by CYP enzymes
- drugs that may decrease plasma concentrations
- inhibitors and inducers of P-gp, BCRP, CYP2B6, CYP2C8, or CYP3A4
Contraindications
- contraindicated in patients for whom Ribavirin is contraindicated
Side Effects
- common side effects observed
- rare adverse events
- risk of symptomatic bradycardia
- reduced hemoglobin, lymphocyte, neutrophil, and platelet count
Pregnancy & Lactation
- contraindicated in pregnant women and men with pregnant partners if administered with Ribavirin
- unknown presence in human breast milk
Precautions & Warnings
- risk of hepatitis B virus reactivation
- serious symptomatic bradycardia when coadministered with Amiodarone
- warnings associated with Ribavirin and Sofosbuvir & Velpatasvir combination treatment
Use in Special Populations
- no clinically relevant effect on exposure to geriatric patients
- pharmacokinetics in patients with renal or hepatic impairment
- hemodialysis efficiency for Sofosbuvir's predominant metabolite
- no specific antidote for overdose
Overdose Effects
- no specific antidote available
- monitoring and supportive measures
- efficiency of hemodialysis
Therapeutic Class
- hepatic viral infections (Hepatitis C)
Storage Conditions
- store in a cool and dry place
- preferably below 30°C
- keep out of reach of children