STK 1.5 million unit (Powder for Injection)

1.5 million unit vial: ৳ 4,500.00

Medicine Details

Category Details
Generic Streptokinase
Company Incepta pharmaceuticals ltd

Indications

  • Management of acute myocardial infarction
  • Lysis of intracoronary thrombi
  • Improvement of ventricular function
  • Reduction of mortality

Pharmacology

  • Forms complex with plasminogen
  • Converts plasminogen to plasmin
  • Breaks down clots and fibrinogen

Dosage & Administration

  • Reconstituted using sodium chloride or dextrose injection
  • IV infusion
  • Intracoronary infusion
  • Specific vial sizes and total solution volumes
  • Loading dose and infusion rates for different conditions

Interaction

  • Increased risk of hemorrhage with anticoagulants
  • Neutralization of heparin by protamine sulfate
  • Combination therapy with aspirin
  • Concomitant use of acetylsalicylic acid
  • Anticoagulation treatment following STK

Contraindications

  • Risk of bleeding
  • Haemorrhagic diathesis
  • Potential for internal bleeding
  • Cerebrovascular accident within 2 months
  • Invasive operations
  • Severe uncontrolled hypertension
  • Severe liver or kidney damage

Side Effects

  • Common: headache, back pain, muscle pain, chills, fever
  • Bleeding at invaded or disturbed sites
  • Allergic-anaphylactic reactions
  • Neurologic symptoms
  • Cardiac complications and vascular disorders
  • Gastrointestinal disorders

Pregnancy & Lactation

  • Pregnancy category C
  • Recommendation to discontinue breastfeeding

Precautions & Warnings

  • Increased likelihood of resistance due to antiSTK antibodies
  • No thrombolytic treatment before 10th postoperative day
  • Increased danger of hemorrhage with anticoagulants
  • Titer of antiSTK antibodies after administration

Use in Special Populations

  • Safety & effectiveness in children not established

Overdose Effects

  • Uncontrollable bleeding
  • Administration of aminocaproic acid or aprotinin

Therapeutic Class

  • Fibrinolytics (Thrombolytics)

Reconstitution

  • Careful reconstitution and dilution
  • Specific reconstitution and dilution procedures
  • Visual inspection prior to administration
  • No preservatives in STK

Storage Conditions

  • Storage temperature for STK vial
  • Physico-chemical stability after reconstitution
  • Usage within 24 hours of reconstitution

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