Maxtra 0.4 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Beacon pharmaceuticals plc

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscle in the bladder neck and prostate
  • Improves urine flow rate and reduces BPH symptoms
  • High plasma protein binding (94% to 99%)
  • Extensively metabolized by cytochrome P 450 enzymes
  • Long elimination half-life (5 to 15 hours)

Dosage & Administration

  • Tamsulosin Hydrochloride 0.4 mg daily, to be taken after meal at night
  • Dose may be increased to 0.8 mg after 2 to 4 weeks if necessary
  • Swallow whole with a glass of water
  • Should not be crunched or chewed

Interaction

  • Concurrent administration with other alfa1-adrenoceptor antagonists can lead to hypotensive effects
  • No interactions seen with atenolol, enalapril, or nifedipine
  • Cimetidine increases plasma levels, frusemide decreases plasma levels
  • No interactions at the level of hepatic metabolism with amitriptyline, salbutamol, glibenclamide, and finasteride
  • Diclofenac and warfarin may increase elimination rate

Contraindications

  • Hypersensitivity to tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Possible reduction in blood pressure leading to syncope
  • Caution required in situations where injury could result
  • Examine patient to exclude other conditions causing BPH symptoms
  • Digital rectal examination and PSA determination prior to treatment and at regular intervals

Side Effects

  • Dizziness
  • Abnormal ejaculation
  • Headache
  • Asthenia
  • Postural hypotension
  • Palpitations

Pregnancy & Lactation

  • Not recommended for use during pregnancy and lactation

Precautions & Warnings

  • Transient postural symptoms may occur during orthostatic provocation testing
  • Not advised in patients with micturition syncope
  • Unclear effect on ability to drive or operate machines
  • Patients should be aware of the possibility of dizziness

Overdose Effects

  • Acute hypotension likely in case of overdosage
  • Cardiovascular support required
  • Renal function monitoring and general supportive measures
  • Gastric lavage and activated charcoal administration in large overdoses

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place below 30°C, protected from light

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