Uropro 0.4 mg (Capsule (Modified Release))

Unit Price: ৳ 9.00 (28's pack: ৳ 252.00)

Medicine Details

Category Details
Generic Tamsulosin hydrochloride
Company Benham pharmaceuticals ltd

Indications

  • Treatment of functional symptoms of Benign Prostatic Hyperplasia (BPH)

Pharmacology

  • Selective alpha1 adrenoceptor blocking agent
  • Relaxes smooth muscle in the bladder neck and prostate
  • Improves urine flow rate
  • Reduces symptoms of BPH
  • Absorption of 90% under fasting conditions
  • Time to maximum concentration reached by four to five hours under fasting conditions
  • Extensively metabolized by cytochrome P 450 enzymes in the liver

Dosage & Administration

  • Daily dosage of Tamsulosin Hydrochloride 0.4 mg (one capsule)
  • To be taken after meal at night
  • Dose may be increased to Tamsulosin Hydrochloride 0.8 mg (two capsules) once daily if necessary
  • Capsule should be swallowed whole with a glass of water (about 150 ml) in the standing or sitting position

Interaction

  • Concurrent administration with other alfa1-adrenoceptor antagonists could lead to hypotensive effects
  • No interactions seen when given concomitantly with atenolol, enalapril, or nifedipine
  • Concomitant cimetidine brings about a rise and frusemide a fall in plasma levels of Uropro
  • No interactions at the level of hepatic metabolism seen during in vitro studies with liver microsomal fractions

Contraindications

  • Hypersensitivity to Tamsulosin hydrochloride
  • History of orthostatic hypotension
  • Severe hepatic insufficiency
  • Reduction in blood pressure can occur, leading to syncope

Side Effects

  • Adverse reactions include dizziness, abnormal ejaculation, headache, asthenia, postural hypotension, and palpitations

Pregnancy & Lactation

  • Not recommended for use in pregnancy and lactation

Precautions & Warnings

  • Transient postural symptoms rarely occur during orthostatic provocation testing after the first dose
  • Use in patients with micturition syncope is not advised
  • No data available on effects on ability to drive or operate machines

Overdose Effects

  • Acute hypotension likely to occur after overdosage
  • Cardiovascular support should be given
  • Renal function should be monitored
  • Gastric lavage can be applied in case of large quantities involved

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Store in a cool and dry place, below 30°C
  • Protected from light

Related Brands