Eziflo-D 0.4 mg+0.5 mg (Capsule)

Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride dutasteride
Company Biopharma limited

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Indications

  • Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH)
  • Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH

Pharmacology

  • Combination of Tamsulosin Hydrochloride and Dutasteride
  • Mechanisms of action to improve symptoms in patients with BPH
  • Tamsulosin Hydrochloride as an antagonist of alpha1A-adrenoreceptors
  • Dutasteride as a dual 5 alpha reductase inhibitor (5ARI)
  • Effects on urine flow rate and reduction in BPH symptoms

Dosage & Administration

  • Recommended dose for adults (including elderly)
  • Administration with or after the same meal each day

Renal impairment

  • Effect of renal impairment on Tamsulosin-Dutasteride pharmacokinetics

Hepatic impairment

  • Effect of hepatic impairment on Tamsulosin-Dutasteride pharmacokinetics
  • Use of caution in patients with mild to moderate hepatic impairment
  • Contra-indication in patients with severe hepatic impairment

Interaction

  • Drug interaction studies for Dutasteride-Tamsulosin combination
  • Effects of other drugs on the pharmacokinetics of Dutasteride
  • Effects of Dutasteride on the pharmacokinetics of other drugs

Contraindications

  • Contra-indication in women, children, and adolescents
  • Contra-indication in patients with hypersensitivity to Dutasteride, Tamsulosin, soya, peanut, or any of the excipients
  • Contra-indication in patients with a history of orthostatic hypotension and severe hepatic impairment

Side Effects

  • Impotence
  • Decreased libido
  • Breast disorders (including breast enlargement and tenderness)
  • Ejaculation disorders
  • Dizziness

Pregnancy & Lactation

  • Contra-indication for use by women
  • Effect of Tamsulosin-Dutasteride combination on pregnancy, lactation, and fertility
  • Effect of Dutasteride on semen characteristics in healthy men
  • Effects of Tamsulosin Hydrochloride on sperm counts or sperm function

Precautions & Warnings

  • Prescription after careful benefit risk assessment
  • Increased risk of adverse events (including cardiac failure)
  • Evaluation for prostate cancer risk including PSA testing
  • Monitoring of PSA values during treatment
  • Prostate cancer and high-grade tumors evaluation
  • Caution in patients with renal impairment
  • Caution in patients with hepatic impairment
  • Risk of hypotension
  • Intraoperative Floppy Iris Syndrome
  • Caution in patients scheduled for cataract surgery
  • Caution in patients with liver disease
  • Risk of breast neoplasia

Overdose Effects

  • No data available on overdosage of Tamsulosin-Dutasteride combination
  • Safety concerns in volunteer studies and clinical studies for Dutasteride
  • Treatment for acute overdose with Tamsulosin Hydrochloride

Storage Conditions

  • Cool and dry place, protected from light

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