Eziflo-D 0.4 mg+0.5 mg (Capsule)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride dutasteride |
| Company | Biopharma limited |
Therapeutic Class
- BPH/ Urinary retention/ Urinary incontinence
Indications
- Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH)
- Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH
Pharmacology
- Combination of Tamsulosin Hydrochloride and Dutasteride
- Mechanisms of action to improve symptoms in patients with BPH
- Tamsulosin Hydrochloride as an antagonist of alpha1A-adrenoreceptors
- Dutasteride as a dual 5 alpha reductase inhibitor (5ARI)
- Effects on urine flow rate and reduction in BPH symptoms
Dosage & Administration
- Recommended dose for adults (including elderly)
- Administration with or after the same meal each day
Renal impairment
- Effect of renal impairment on Tamsulosin-Dutasteride pharmacokinetics
Hepatic impairment
- Effect of hepatic impairment on Tamsulosin-Dutasteride pharmacokinetics
- Use of caution in patients with mild to moderate hepatic impairment
- Contra-indication in patients with severe hepatic impairment
Interaction
- Drug interaction studies for Dutasteride-Tamsulosin combination
- Effects of other drugs on the pharmacokinetics of Dutasteride
- Effects of Dutasteride on the pharmacokinetics of other drugs
Contraindications
- Contra-indication in women, children, and adolescents
- Contra-indication in patients with hypersensitivity to Dutasteride, Tamsulosin, soya, peanut, or any of the excipients
- Contra-indication in patients with a history of orthostatic hypotension and severe hepatic impairment
Side Effects
- Impotence
- Decreased libido
- Breast disorders (including breast enlargement and tenderness)
- Ejaculation disorders
- Dizziness
Pregnancy & Lactation
- Contra-indication for use by women
- Effect of Tamsulosin-Dutasteride combination on pregnancy, lactation, and fertility
- Effect of Dutasteride on semen characteristics in healthy men
- Effects of Tamsulosin Hydrochloride on sperm counts or sperm function
Precautions & Warnings
- Prescription after careful benefit risk assessment
- Increased risk of adverse events (including cardiac failure)
- Evaluation for prostate cancer risk including PSA testing
- Monitoring of PSA values during treatment
- Prostate cancer and high-grade tumors evaluation
- Caution in patients with renal impairment
- Caution in patients with hepatic impairment
- Risk of hypotension
- Intraoperative Floppy Iris Syndrome
- Caution in patients scheduled for cataract surgery
- Caution in patients with liver disease
- Risk of breast neoplasia
Overdose Effects
- No data available on overdosage of Tamsulosin-Dutasteride combination
- Safety concerns in volunteer studies and clinical studies for Dutasteride
- Treatment for acute overdose with Tamsulosin Hydrochloride
Storage Conditions
- Cool and dry place, protected from light