Urocap-D 0.4 mg+0.5 mg (Capsule)
Unit Price: ৳ 20.00 (3 x 10: ৳ 600.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride dutasteride |
| Company | Ibn sina pharmaceuticals ltd |
Indications
- Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH)
- Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH
Pharmacology
- Alpha<sub>1A</sub>-adrenoreceptors antagonist
- Dual 5 alpha reductase inhibitor (5ARI)
- Inhibition of alpha<sub>1</sub>-adrenoreceptors in the stromal prostatic smooth muscle and bladder neck
- Reduction in prostate volume by inhibiting the conversion of Testosterone to Dihydrotestosterone (DHT)
Dosage & Administration
- Recommended dose: Tamsulosin Hydrochloride 0.4 mg & Dutasteride 0.5 mg
- Oral administration approximately 30 minutes after the same meal each day
- Swallow whole, not chewed or opened
Interaction
- No formal drug interaction studies for Dutasteride-Tamsulosin combination
- Metabolism primarily catalyzed by CYP3A4 and CYP3A5
- Possible increase in Dutasteride serum concentrations when used with CYP3A4 and/or P-glycoprotein-inhibitors
Contraindications
- Contra-indicated in women, children, adolescents, and patients with hypersensitivity to active ingredients or excipients
Side Effects
- Impotence
- Decreased libido
- Breast disorders
- Ejaculation disorders
- Dizziness
Pregnancy & Lactation
- Contra-indicated for use by women
- Effect on male fertility reported for Dutasteride
- Risk of adverse effects on male foetus if exposed
Precautions & Warnings
- Prescribe after careful benefit risk assessment
- Increased risk of adverse events including cardiac failure
- Effects on prostate specific antigen (PSA) and prostate cancer detection
- Regular evaluation for prostate cancer risk
- Caution in patients with renal impairment, hypotension, and hepatic impairment
- Potential occurrence of Intraoperative Floppy Iris Syndrome (IFIS) during cataract surgery
Overdose Effects
- No specific data available for Tamsulosin-Dutasteride combination overdose
- In volunteer studies, daily doses of Dutasteride up to 40 mg/day administered for 7 days without significant safety concerns
- Acute overdose with Tamsulosin Hydrochloride reported with symptoms such as acute hypotension, vomiting, and diarrhea
Therapeutic Class
- BPH/ Urinary retention/ Urinary incontinence
Storage Conditions
- Store in a cool and dry place, protected from light