Maxrin D 0.4 mg+0.5 mg (Capsule)

Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00

Medicine Details

Category Details
Generic Tamsulosin hydrochloride dutasteride
Company Square pharmaceuticals plc

Indications

  • Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH).
  • Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH.

Pharmacology

  • Combination of Tamsulosin Hydrochloride and Dutasteride
  • Improvement in urine flow rate
  • Reduction in symptoms of BPH
  • Mechanism of action of Tamsulosin
  • Mechanism of action of Dutasteride
  • Effect on alpha1-adrenoreceptors
  • Effect on 5 alpha reductase isoenzymes
  • Inhibition of testosterone conversion to Dihydrotestosterone (DHT)

Dosage & Administration

  • Recommended adult dose
  • Oral administration
  • Recommendation for swallowing the capsule whole
  • Guidelines for usage in renal impairment
  • Guidelines for usage in hepatic impairment

Interaction

  • Drug interaction studies
  • Effects of other drugs on the pharmacokinetics of Dutasteride
  • Effects of Dutasteride on the pharmacokinetics of other drugs
  • Potential drug interactions with Tamsulosin Hydrochloride

Contraindications

  • Contra-indicated in women and children and adolescents
  • Hypersensitivity to Dutasteride or Tamsulosin
  • Exposure to soya, peanut, or any of the excipients
  • History of orthostatic hypotension
  • Severe hepatic impairment

Side Effects

  • Impotence
  • Decreased libido
  • Breast disorders
  • Ejaculation disorders
  • Dizziness

Pregnancy & Lactation

  • Contra-indicated for use by women
  • Effects on male fertility
  • Potential effects on foetus due to Dutasteride exposure
  • Effects on lactation

Precautions & Warnings

  • Careful benefit risk assessment for combination therapy
  • Potential increased risk of adverse events, including cardiac failure
  • Effects on prostate specific antigen (PSA) and prostate cancer detection
  • Regular evaluation for prostate cancer risk
  • Caution in renal impairment
  • Potential for hypotension
  • Intraoperative Floppy Iris Syndrome (IFIS)
  • Dutasteride absorption through the skin
  • Caution in hepatic impairment
  • Considerations for breast neoplasia

Overdose Effects

  • No data available for Tamsulosin-Dutasteride combination
  • Safety concerns of Dutasteride at high doses
  • Treatment for overdose of Tamsulosin

Therapeutic Class

  • BPH/ Urinary retention/ Urinary incontinence

Storage Conditions

  • Cool and dry place, protected from light

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