Maxrin D 0.4 mg+0.5 mg (Capsule)
Unit Price: ৳ 20.00 (2 x 10: ৳ 400.00)
Strip Price: ৳ 200.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tamsulosin hydrochloride dutasteride |
| Company | Square pharmaceuticals plc |
Indications
- Treatment of moderate to severe symptoms of benign prostatic hyperplasia (BPH).
- Reduction in the risk of acute urinary retention and surgery in patients with moderate to severe symptoms of BPH.
Pharmacology
- Combination of Tamsulosin Hydrochloride and Dutasteride
- Improvement in urine flow rate
- Reduction in symptoms of BPH
- Mechanism of action of Tamsulosin
- Mechanism of action of Dutasteride
- Effect on alpha1-adrenoreceptors
- Effect on 5 alpha reductase isoenzymes
- Inhibition of testosterone conversion to Dihydrotestosterone (DHT)
Dosage & Administration
- Recommended adult dose
- Oral administration
- Recommendation for swallowing the capsule whole
- Guidelines for usage in renal impairment
- Guidelines for usage in hepatic impairment
Interaction
- Drug interaction studies
- Effects of other drugs on the pharmacokinetics of Dutasteride
- Effects of Dutasteride on the pharmacokinetics of other drugs
- Potential drug interactions with Tamsulosin Hydrochloride
Contraindications
- Contra-indicated in women and children and adolescents
- Hypersensitivity to Dutasteride or Tamsulosin
- Exposure to soya, peanut, or any of the excipients
- History of orthostatic hypotension
- Severe hepatic impairment
Side Effects
- Impotence
- Decreased libido
- Breast disorders
- Ejaculation disorders
- Dizziness
Pregnancy & Lactation
- Contra-indicated for use by women
- Effects on male fertility
- Potential effects on foetus due to Dutasteride exposure
- Effects on lactation
Precautions & Warnings
- Careful benefit risk assessment for combination therapy
- Potential increased risk of adverse events, including cardiac failure
- Effects on prostate specific antigen (PSA) and prostate cancer detection
- Regular evaluation for prostate cancer risk
- Caution in renal impairment
- Potential for hypotension
- Intraoperative Floppy Iris Syndrome (IFIS)
- Dutasteride absorption through the skin
- Caution in hepatic impairment
- Considerations for breast neoplasia
Overdose Effects
- No data available for Tamsulosin-Dutasteride combination
- Safety concerns of Dutasteride at high doses
- Treatment for overdose of Tamsulosin
Therapeutic Class
- BPH/ Urinary retention/ Urinary incontinence
Storage Conditions
- Cool and dry place, protected from light