Tolfi 200 mg (Tablet)

Unit Price: ৳ 10.00 (3 x 10: ৳ 300.00)
Strip Price: ৳ 100.00

Medicine Details

Category Details
Generic Tolfenamic acid
Company Benham pharmaceuticals ltd

Title

  • Tolfi 200 mg Tablet

Categories

  • Analgesic
  • Anti-inflammatory
  • Migraine Relief
  • Pain Management
  • NSAID

Description

  • Mode of Action: Inhibits cyclooxygenase enzyme, inhibits synthesis of inflammatory mediators, has direct antagonistic action on its receptors
  • Indications:
    • Relieving the pain of migraine headache
    • Analgesic in post-operative pain and fever
  • Pharmacokinetic Properties:
    • Readily absorbed from GI tract
    • Peak plasma concentration: 60-90 min
    • Bioavailability: 85%
    • Protein-binding: 99%
    • Plasma half-life: 2 hours
    • Metabolised in the liver
    • Enterohepatic circulation
    • Excreted in urine (90%) and feces
  • Dosage & Administration:
    • Acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
    • Mild to moderate pain: 100-200 mg tid
    • Dose adjustments for renal impairment
    • Should be taken with food
    • Take with water during or immediately after meals
  • Interactions: Interacts with Metoclopramide, Magnesium hydroxide, Aluminium hydroxide, anticoagulants, other NSAIDs, loop diuretics, B-blockers, ACE Inhibitors, Lithium, Methotrexate, cardiac glycosides, ACE inhibitors, Ciclosporin, Tacrolimus, diuretics
  • Contraindications:
    • Active gastro-intestinal bleeding
    • Active gastro-intestinal ulceration
    • Severe heart failure
  • Side Effects:
    • Alveolitis
    • Hepatic damage
    • Pancreatitis
    • Pulmonary eosinophilia
    • Stevens-johnson syndrome
    • Angioedema
    • Blood disorder
    • Depression
    • Diarrhea
    • Dizziness
    • Drowsiness
    • Dysuria
    • Euphoria
    • Gastro-intestinal bleeding
    • Hallucination
    • Insomnia
    • Malaise
    • Nausea
    • Hearing disturbances
    • Rash
    • Visual disturbances
    • Vertigo
    • Raised blood pressure
  • Pregnancy & Lactation: Not recommended during pregnancy, avoidance recommended during breastfeeding
  • Precautions & Warnings:
    • Patients with asthma
    • Bleeding disorders
    • Cardiovascular diseases
    • Peptic ulceration
    • Hypertension
    • Liver infection
    • Cardiac or renal function impairment
    • Elderly
    • Increase water intake or dose reduction to reduce dysuria
  • Overdose Effects: Headache, nausea, vomiting, gastrointestinal bleeding, diarrhea, excitation, coma, drowsiness, dizziness, tinnitus, fainting, convulsions, acute renal failure, liver damage
  • Therapeutic Class:
    • Rheumatoid Arthritis
    • Non-steroidal Anti-inflammatory Drugs (NSAIDs)
    • Other drugs for migraine
  • Storage Conditions: Store in a cool and dry place, away from light, keep out of the reach of children
  • Chemical Structure:
    • Molecular Formula: C14H12ClNO2
    • Chemical Structure Image: https://medex.com.bd/storage/res/g-res-1092-tolfenamic-acid-chemical-structure-dzPweN5r9IE4mD1xFrIL.svg
  • Common Questions:
    • What is Tolfi 200 mg Tablet?: A potent inhibitor of cyclooxygenase enzyme, inhibits the synthesis of important inflammatory mediators
    • Uses:
      • Treatment of acute migraine attacks
      • Treatment of mild to moderate pain
    • Quick Tips:
      • Take with food or milk to avoid upset stomach
      • Can cause serious complications if taken for a long time
      • Can raise risk of blood clots, heart attack, or stroke
      • Inform doctor if pregnant, planning to conceive, breastfeeding, or diagnosed with kidney or liver problems

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