Lograin 200 mg (Tablet)
Medicine Details
| Category | Details |
|---|---|
| Generic | Tolfenamic acid |
| Company | Ibn sina pharmaceuticals ltd |
Title
Lograin 200 mg Tablet
Categories
- Analgesic
- NSAID
- Migraine Relief
Description
Lograin 200 mg Tablet is a potent inhibitor of cyclooxygenase enzyme, used for relieving the pain of migraine headache, post-operative pain, and fever. It inhibits the synthesis of important inflammatory mediators such as thromboxane (TX) B2 and prostaglandin (PG) E2.
Dimensions
N/A
Color options
- White
Functions
- Relieves migraine headache
- Acts as analgesic for post-operative pain and fever
- Inhibits cyclooxygenase enzyme
Materials
N/A
Technical specifications
- Molecular Formula: C14H12ClNO2
- Chemical Structure: https://medex.com.bd/storage/res/g-res-1092-tolfenamic-acid-chemical-structure-dzPweN5r9IE4mD1xFrIL.svg
Design elements
N/A
Usability features
- Should be taken with food or milk to avoid stomach upset
- Recommended to take water during or immediately after meals
- Avoid long-term usage to prevent stomach bleeding and kidney problems
- Inform doctor before use if pregnant, planning to conceive, or breastfeeding
- Inform doctor of any history of kidney or liver problems
Dosage instructions
- Adult:
- Acute migraine attacks: 200 mg when symptoms appear, may be repeated once after 1-2 hours
- Mild to moderate pain: 100-200 mg three times a day
- Renal impairment: Dose adjustments may be needed
- Severe renal impairment: Avoid
- Children: A pediatric dosage regimen has not yet been established
Interaction
- Increases Absorption With:
- Metoclopramide
- Magnesium hydroxide
- Decreases Absorption With:
- Aluminium hydroxide
- Increased Risk With:
- Anticoagulants
- Other NSAIDs
- Loop diuretics
- B-blockers
- ACE Inhibitors
- Lithium
- Methotrexate
- Cardiac glycosides
- Increased Risk of Nephrotoxicity With:
- ACE inhibitors
- Ciclosporin
- Tacrolimus
- Diuretics
Contraindications
- Active gastrointestinal bleeding
- Active gastrointestinal ulceration
- Severe heart failure
- History of gastrointestinal bleeding related to previous NSAID therapy
- History of gastrointestinal haemorrhage
- History of gastrointestinal perforation related to previous NSAID therapy
- History of recurrent gastrointestinal ulceration
Side effects
- Alveolitis
- Hepatic damage
- Pancreatitis
- Pulmonary eosinophilia
- Stevens-Johnson syndrome
- Angioedema
- Blood disorder
- Depression
- Diarrhea
- Dizziness
- Drowsiness
- Dysuria
- Euphoria
- Gastrointestinal bleeding
- Gastrointestinal discomfort
- Hallucination
- Insomnia
- Malaise
- Nausea
- Hearing disturbances
- Rash
- Visual disturbances
- Vertigo
- Increased blood pressure
Pregnancy and lactation
- Pregnancy: Not recommended unless essential as per doctor's advice, avoid during third trimester
- Lactation: NSAIDs can appear in breast milk in very low concentrations, if possible, be avoided when breastfeeding
Precautions and warnings
Precautions should be taken for patients with asthma, bronchospasm, bleeding disorders, cardiovascular diseases, peptic ulceration, hypertension, liver infection, cardiac or renal function impairment, and elderly. Increase water intake or dose reduction to reduce dysuria.
Overdose effects
Symptoms include headache, nausea, vomiting, epigastric pain, gastrointestinal bleeding, diarrhea, excitation, coma, drowsiness, dizziness, tinnitus, fainting, and convulsions. Significant poisoning may lead to acute renal failure and liver damage. Patients should be treated symptomatically as required.
Therapeutic class
- Rheumatoid Arthritis
- Non-steroidal Anti-inflammatory Drugs (NSAIDs)
- Other drugs for migraine
Storage conditions
Store in a cool and dry place, away from light. Keep out of the reach of children.