Probis 2.5 mg (Tablet)

Unit Price: ৳ 6.02 (5 x 10: ৳ 301.00)
Strip Price: ৳ 60.20

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Aci limited
Also available as
Probis 5 mg tablet Probis 125 mg tablet

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective ß1 blocker
  • Reduces heart rate and cardiac output
  • Low inter and intra-individual variability
  • High absorption rate
  • Extensively distributed
  • Metabolized via oxidative pathways
  • Renally excreted
  • Metabolized primarily via CYPSA4
  • Balanced clearance between renal elimination and hepatic metabolism
  • Elimination half-life of 10-12 hours

Dosage & Administration

  • Usual starting dose of 5 mg once daily
  • Dose titration interval of 2 weeks
  • Increasing the dose beyond 20 mg once daily produces only a small incremental benefit

Interaction

  • Not recommended to combine with other β-blocking agents
  • Closely monitor patients receiving catecholamine-depleting drugs
  • Use with care when myocardial depressants or inhibitors of A-V conduction are used concurrently

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut
  • Nausea
  • Vomiting
  • Diarrhea
  • Constipation
  • Abdominal pain
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties

Pregnancy & Lactation

  • Not teratogenic in rats at doses up to 150 mg/kg/day
  • Fetotoxic at 50 mg/kg/day and maternotoxic at 150 mg/kg/day
  • Not teratogenic in rabbits at doses up to 12.5 mg/kg/day
  • Embryolethal at 12.5 mg/kg/day
  • Use during pregnancy only if the potential benefit justifies the potential risk to the fetus
  • Small amounts detected in the milk of lactating rats
  • Not known whether excreted in human milk

Precautions & Warnings

  • Use caution in adjusting the dose in patients with renal or hepatic impairment
  • Patients with a history of severe anaphylactic reaction may be more reactive to repeated challenge
  • Unresponsive to the usual doses of epinephrine used to treat allergic reactions

Therapeutic Class

  • Anti adrenergic agent (Beta blockers)
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula: C18H31NO4

Common Questions about Probis 2.5 mg Tablet

  • Beta-blocker medication
  • Used for high blood pressure, chest pain, and heart failure
  • Best taken by mouth once daily, with or without food
  • Common side effects include dizziness, fatigue, headache, slow heart rate, difficulty breathing, and cold hands and feet
  • Generally safe to take, but should be used with caution in certain health conditions
  • Should be taken after food in a prescribed dosage
  • Store in a cool dry place and in its original packaging

Related Brands