Probis 5 mg (Tablet)

Unit Price: ৳ 10.03 (5 x 10: ৳ 501.50)
Strip Price: ৳ 100.30

Medicine Details

Category Details
Generic Bisoprolol hemifumarate
Company Aci limited
Also available as
Probis 25 mg tablet Probis 125 mg tablet

Title

  • Probis 5 mg Tablet

Categories

  • Medicine
  • Beta-blocker

Indications

  • Hypertension
  • Angina
  • Moderate to severe heart failure

Pharmacology

  • Selective ß1 blocker
  • Reduces heart rate
  • Reduces cardiac output
  • Decreases arterial hypertension
  • Unchanged cholesterol fraction including HDL-cholesterol in long-term therapy
  • Single daily dose
  • Low inter and intra-individual variability of plasma concentration profiles
  • High therapeutic reliability

Dosage & Administration

  • Usual starting dose of 5 mg once daily for mild to moderate hypertension
  • Dose may be increased to 10 mg or 20 mg once daily if necessary
  • Dose titration interval of 2 weeks
  • No established safety and effectiveness in children
  • Initial daily dose of 5 mg recommended for patients with hepatic or renal impairment
  • No need for drug replacement in patients undergoing dialysis
  • No adjustment of dose required in the elderly unless significant renal or hepatic dysfunction

Interaction

  • Not recommended in combination with other β-blocking agents
  • Close monitoring required when used with catecholamine-depleting drugs
  • Caution when coadministered with centrally active antihypertensive agents or antiarrhythmic agents
  • Combined use with calcium channel blockers with negative inotropic effects may lead to severe hypotension, bradycardia, and cardiac failure

Contraindications

  • Cardiogenic shock
  • Overt heart failure
  • Second or third degree A-V block
  • Right ventricular failure secondary to pulmonary hypertension
  • Sinus bradycardia

Side Effects

  • Fatigue
  • Dizziness
  • Headache
  • Disturbances of the gut (nausea, vomiting, etc.)
  • Cold or numb extremities
  • Muscle weakness or cramps
  • Breathing difficulties due to bronchospasm in people with asthma or COPD

Pregnancy & Lactation

  • Potential risk to the fetus, consider only if benefits justify the risk
  • Not known if excreted in human milk, nursing mothers should stop nursing if essential use is considered
  • Studies in pregnant women not available

Precautions & Warnings

  • Use caution in adjusting the dose in patients with renal or hepatic impairment
  • Patients with a history of severe anaphylactic reaction may be more reactive to allergens
  • Unresponsive to usual doses of epinephrine used to treat allergic reactions

Therapeutic Class

  • Anti adrenergic agent (Beta blockers)
  • Beta-adrenoceptor blocking drugs
  • Beta-blockers

Storage Conditions

  • Keep in a dry place away from light and heat
  • Keep out of the reach of children

Chemical Structure

  • Molecular Formula : C18H31NO4

Common Questions

  • Probis 5 mg Tablet is a beta-blocker medication
  • Used for High blood pressure (hypertension), Chest pain (angina), and Heart failure
  • Recommended to be taken by mouth, with or without food, once daily
  • Possible side effects include Dizziness, Fatigue, Headache, and Difficulty breathing
  • Safe to take but consult a doctor if having health conditions such as Asthma, Diabetes, etc.
  • Should be taken after food in a prescribed dosage
  • Store in a cool dry place and in its original packaging
  • May cause dizziness, monitor blood sugar levels regularly, and avoid sudden discontinuation to prevent sudden rise in blood pressure

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