Texamic 500 mg (Capsule)
Unit Price: ৳ 22.00 (2 x 10: ৳ 440.00)
Strip Price: ৳ 220.00
Medicine Details
| Category | Details |
|---|---|
| Generic | Tranexamic acid |
| Company | Euro pharma ltd |
Indications
- Prophylaxis and therapy of hemophtoes
- Digestive hemorrhages
- Hemorrhagic syndromes in leukemia
- Cirrhosis and hemophilia
- Thrombocytopenic purpura
- Hematurias
- Post-partum and puerperium hemorrhages
- Functional menometrorrhagias
- Idiopathic or IUD(lntra uterine Device) induced menorrhagias
- Prophylaxis and antihemorrhagic therapy during operations
- Therapy of hemorrhagic manifestations
- Prophylaxis and antihemorrhagic therapy of prostatic, vesical and renal surgery
- Prophylaxis and antihemorrhagic therapy during a tonsillectomy
Pharmacology
- Tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid)
- Strong antifibrinolytic action
- Low acute and chronic toxicity
- Well absorbed by oral route
- Inhibition of plasminogen activation
- No interference with clotting processes
- No tendency to thrombophilia
Dosage & Administration
- Usual dose: 500-1000 mg 3 times daily for adults
- Mean recommended daily doses: 0.5-1 gm orally, 500 mg by parenteral route for prophylaxis
- Increased oral dose for therapy of hemorrhagic manifestations
- Dosage for children based on body weight
- No reduction in dosage for elderly patients unless evidence of renal failure
Interaction
- Incompatible with solutions containing penicillins
- Antagonizes the action of streptokinase & urokinase
- Potential for increased thrombus formation with estrogen-containing drugs
- Direct admixture with whole blood should be avoided during transfusion
Contraindications
- Known individual hypersensitivity to the product
- Thromboembolic disease
- Arterial and venous thrombosis
- Endocavitary hemorrhages
- Serious kidney failure
Side Effects
- Sense of fatigue
- Conjunctival irritation
- Nasal blockage
- Itching
- Skin reddening
- Exanthems
- Nausea
- Diarrhea
- Gastric pyrosis
- Postural hypotension
Pregnancy & Lactation
- Should not be administered during known and presumed pregnancy
- Passes into breast milk at low concentration
Precautions & Warnings
- Use in cases of hyperfibrinolysis
- Prophylactic treatment 24 hours before operation
- Therapy of hemorrhages prolonged for at least 24 hours after manifestations have disappeared
- Caution in hematuria
- Avoid in serious renal insufficiency or anuric syndromes
- Particular care in cardiopathic and hepatopathic subjects
Therapeutic Class
- Anti-fibrinolytic drugs
- Hemostatic drugs
Storage Conditions
- Store in a dry place at 15-30°C
- Away from light
- Keep out of children's reach